ArticleBiological psychiatry2022
Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Temperament, personality, and psychopathology in youth: A preregistered multilevel meta-analytic review and preregistered large-scale replication and extension.Psychological bulletin · 2026Pooled it
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- Concurrent Supervised-Unsupervised Representative Subspace Clustering (CSU-RSC).bioRxiv : the preprint server for biology · 2026Article
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
- Early Adversity Selectively Reshapes the Somato-Cognitive Action Network in the Developing Brain.bioRxiv : the preprint server for biology · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- BrainUMA: A Unified multi-atlas learning framework for brain disorders diagnosis.Medical & biological engineering & computing · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.bioRxiv : the preprint server for biology · 2026Article
- Individual-specific functional connectivity predicts clinical symptoms severity in patients with post-traumatic stress disorder.BMC psychiatry · 2026Article
- Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.bioRxiv : the preprint server for biology · 2025Article
- Spatial development of brain networks during the first six postnatal months.Communications biology · 2025Article
- Development of areal-level individualized homologous functional parcellations in youth.Communications biology · 2025Article
- Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025Article
- Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning.bioRxiv : the preprint server for biology · 2025Article
- Individualized cerebellar damage predicts the presence of behavioral disorders in children with brainstem tumors.Communications medicine · 2025Article
- Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents.Journal of mood and anxiety disorders · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
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Authors and funding
21 authors.
Funding
Abstract
backgroundThe spatial layout of large-scale functional brain networks differs between individuals and is particularly variable in the association cortex, implicated in a broad range of psychiatric disorders. However, it remains unknown whether this variation in functional topography is related to major dimensions of psychopathology in youth.
methodsThe authors studied 790 youths ages 8 to 23 years who had 27 minutes of high-quality functional magnetic resonance imaging data as part of the Philadelphia Neurodevelopmental Cohort. Four correlated dimensions were estimated using a confirmatory correlated traits factor analysis on 112 item-level clinical symptoms, and one overall psychopathology factor with 4 orthogonal dimensions were extracted using a confirmatory factor analysis. Spatially regularized nonnegative matrix factorization was used to identify 17 individual-specific functional networks for each participant. Partial least square regression with split-half cross-validation was conducted to evaluate to what extent the topography of personalized functional networks encodes major dimensions of psychopathology.
resultsPersonalized functional network topography significantly predicted unseen individuals' major dimensions of psychopathology, including fear, psychosis, externalizing, and anxious-misery. Reduced representation of association networks was among the most important features for the prediction of all 4 dimensions. Further analysis revealed that personalized functional network topography predicted overall psychopathology (r = 0.16, permutation testing p < .001), which drove prediction of the 4 correlated dimensions.
conclusionsThese results suggest that individual differences in functional network topography in association networks is related to overall psychopathology in youth. Such results underscore the importance of considering functional neuroanatomy for personalized diagnostics and therapeutics in psychiatry.
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