ArticleMedical engineering & physics2022
Aging-related structural change in 3D extracellular matrix affects its mechanics.
Article in Medical engineering & physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Extracellular matrix: new insights into its role in female reproductive aging and potential therapeutic strategies.npj aging · 2026Review
- Influence of biophysical and biochemical cues on Plasmodium sporozoite dynamics in skin tissue.Parasites & vectors · 2025Review
- Raman Spectroscopy in Cellular and Tissue Aging Research.Aging cell · 2025Review
- Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ-on-a-Chip Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Microphysiological systems for human aging research.Aging cell · 2024Review
- Experimental validation for the interconversion between generalized Kelvin-Voigt and Maxwell models using human skin tissues.Journal of biomechanics · 2024Article
- Chronic inflammation and the hallmarks of aging.Molecular metabolism · 2023Review
- Lactic Acid Bacteria Improve the Photoprotective Effect via MAPK/AP-1/MMP Signaling Pathway on Skin Fibroblasts.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aging induces marked alterations in the structural, mechanical, and transport properties in the extracellular matrix (ECM). To provide computational data on the impact of aging-related changes on ECM mechanical quantities and transport properties, we developed a computational model for the aging-related ECM fibrous network. A finite volume method was utilized to calculate the velocity field, pressure loss, hydraulic conductivity and drag force. Our results quantitatively demonstrated that the hydraulic conductivity in most of the aging ECM-mimetic fibrous networks tends to be significantly lower than young ECM-mimetic fibrous networks, while pressure loss and drag force show the opposite trend. All these findings highlight that such altered mechanical quantities and transport properties during aging can be important biological cues to assess the aging process and eventually provide insights in treating aging-related diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.