Evidence map›Paper›PMID 35926685›Full record

ArticleAmerican journal of infection control2023

The importance of targeting intraoperative transmission of bacteria with antibiotic resistance and strain characteristics.

Randy W Loftus, Franklin Dexter, Jeremiah Brown

Abstract read
In one paragraph

Article in American journal of infection control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Randy W LoftusThe University of Iowa, Iowa City, IA. Electronic address: randy-loftus@uiowa.edu.
Franklin DexterThe University of Iowa, Iowa City, IA.
Jeremiah BrownDartmouth Geisel School of Medicine, Hanover, NH.

Funding

The BASIC trial: Improving implementation of evidence-based approaches and surveillance to prevent bacterial transmission and infectionR01AI155752 · NIAID · DARTMOUTH COLLEGE · PI BROWN, JEREMIAH R, LOFTUS, RANDY W · 2021 to 2025
$4.0M
NIAID NIH HHS R01 AI155752
6 · The paper itself

Abstract

backgroundEvidence-based intraoperative infection control measures can reduce Staphylococcus aureus transmission and infections. We aimed to determine whether transmitted S. aureus isolates were associated with increased risk of multidrug resistance and associated traits.

methodsS. aureus isolates obtained from intraoperative environmental, patient skin, and provider hand reservoirs among 274 operating room case pairs (1

resultsTransmitted isolates (N=58) were associated with increased risk of multi-drug antibiotic resistance [33% (19/58) transmitted vs. 10% (12/115) other isolates, risk ratio 3.14, 99% CI 1.34-7.38, P=0.0006]. Transmission was associated with a significant increase in resistance traits including mecA [40% transmitted isolates vs. 17% other isolates, risk ratio 2.28, P=0.0026] and ant (6)-Ia [26% transmitted isolates vs. 9% other isolates, risk ratio 2.97, P=0.0050]. Provider hands were a frequent reservoir of origin, between-case a common mode of transmission, and patient skin and provider hands frequent transmission locations for multidrug resistant pathogens.

conclusionsIntraoperative S. aureus transmission was associated with multidrug resistance and resistance traits. Proven infection control measures should be leveraged to target intraoperative transmission of multidrug resistant pathogens.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsDrug Resistance, MicrobialHumansInfection ControlMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsAntibiotic resistanceAntibiotic stewardshipInfection controlIntraoperative period and pathogen transmissionSurgical site infection

Identifiers

PMID35926685
PMCPMC10918765

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.