Evidence map›Paper›PMID 35926505›Full record

ArticleCell reports. Medicine2022

Immunogenicity and reactogenicity of heterologous immunization against SARS CoV-2 using Sputnik V, ChAdOx1-S, BBIBP-CorV, Ad5-nCoV, and mRNA-1273.

Carla A Pascuale, Augusto Varese, Diego S Ojeda, Marina E Pasinovich, Laura Lopez, Andres H Rossi, Pamela E Rodriguez, Esteban A Miglietta, Laboratorio SeVa Group, Ignacio Mazzitelli and 47 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Review
  3. Developing the next-generation of adenoviral vector vaccines.Human vaccines & immunotherapeutics · 2025
    Review
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Construction and application of adenoviral vectors.Molecular therapy. Nucleic acids · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors at 9 institutions in 1 country.

Carla A PascualeFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Augusto VareseINBIRS-CONICET, Facultad de Medicina UBA, Buenos Aires, Argentina.
Diego S OjedaFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Marina E PasinovichMinisterio de Salud de la Nación, Buenos Aires, Argentina.
Laura LopezMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Andres H RossiFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Pamela E RodriguezFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Esteban A MigliettaFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Laboratorio SeVa GroupFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Ignacio MazzitelliINBIRS-CONICET, Facultad de Medicina UBA, Buenos Aires, Argentina.
Facundo Di Diego GarciaINBIRS-CONICET, Facultad de Medicina UBA, Buenos Aires, Argentina.
Lautaro SanchezFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Santiago Oviedo RoucoFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
María Mora Gonzalez Lopez LedesmaFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina.
Juan Pablo ZuranoInstituto de Biología Subtropical (IBS), Universidad Nacional de Misiones (UNaM)-CONICET, Misiones, Argentina.
Bianca MazzitelliINBIRS-CONICET, Facultad de Medicina UBA, Buenos Aires, Argentina.
Graciela ScruzziMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Paula BarberoMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Diego CardozoMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Sandra GallegoInstituto de Virología "Dr. J. M. Vanella", Córdoba, Argentina.
Mariel BordaMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Miguel DiazMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Ministerio de Salud de la Provincia de Córdoba GroupMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
UNC-Fac. Cs. Médicas-InViV GroupInstituto de Virología "Dr. J. M. Vanella", Córdoba, Argentina.
Francisco RidaoCentro de Investigación en Medicina Traslacional (CIMT), Ministerio de Salud de la Pcia de La Rioja, La Rioja, Argentina.
Angela Brigido RosalesCentro de Investigación en Medicina Traslacional (CIMT), Ministerio de Salud de la Pcia de La Rioja, La Rioja, Argentina.
Ministerio de Salud de la Provincia de La Rioja GroupCentro de Investigación en Medicina Traslacional (CIMT), Ministerio de Salud de la Pcia de La Rioja, La Rioja, Argentina.
Jorge BhonLaboratorio de Salud Pública "Dalmiro Pérez Laborda" Ministerio de Salud de la Pcia de San Luis, San Luis, Argentina.
Juan M TaliaLaboratorio de Salud Pública "Dalmiro Pérez Laborda" Ministerio de Salud de la Pcia de San Luis, San Luis, Argentina.
María E DiangeloServicio de Inmunizaciones, Programa Epidemiología, Ministerio de Salud de la Pcia de San Luis, San Luis, Argentina.
María A LacazeLaboratorio de Salud Pública "Dalmiro Pérez Laborda" Ministerio de Salud de la Pcia de San Luis, San Luis, Argentina.
Ministerio de Salud de la Provincia de San Luis GroupLaboratorio de Salud Pública "Dalmiro Pérez Laborda" Ministerio de Salud de la Pcia de San Luis, San Luis, Argentina.
Balanzino AimeHospital Interzonal General de Agudos San Martín, Pcia de Buenos Aires, Argentina.
Sebastian Isaac GutierrezHospital Interzonal General de Agudos San Martín, Pcia de Buenos Aires, Argentina.
Regina ErcoleHospital Interzonal Especializado de Agudos y Crónicos San Juan de Dios, Pcia de Buenos Aires, Argentina.
Rosana ToroHospital Interzonal General de Agudos San Roque, Pcia de Buenos Aires, Argentina.
Lorena TauLaboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Pcia de Buenos Aires, Argentina.
Laura DelaplaceLaboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Pcia de Buenos Aires, Argentina.
Malena Ferreyra CompagnucciLaboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Pcia de Buenos Aires, Argentina.
Universidad Nacional de La Plata GroupLaboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Pcia de Buenos Aires, Argentina.
Celeste SartoriHospital Subzonal Especializado Elina de la Serna de Montes de Oca, Pcia de Buenos Aires, Argentina.
Isabel DesimoneHospital Interzonal General de Agudos Evita, Pcia de Buenos Aires, Argentina.
Cecilia EchegoyenHospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi, Pcia de Buenos Aires, Argentina.
Pilar VelazquezMinisterio de Salud de la Pcia de Buenos Aires, Pcia de Buenos Aires, Argentina.
Clarisa TestaMinisterio de Salud de la Pcia de Buenos Aires, Pcia de Buenos Aires, Argentina.
Ministerio de Salud de la Provincia de Buenos Aires GroupMinisterio de Salud de la Pcia de Buenos Aires, Pcia de Buenos Aires, Argentina.
Daniela HozborLaboratorio VacSal, Facultad de Ciencias Exactas, Universidad Nacional de la Plata, Pcia de Buenos Aires, Argentina.
Guillermo DocenaLaboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Pcia de Buenos Aires, Argentina.
Carlos H LainoCentro de Investigación en Medicina Traslacional (CIMT), Ministerio de Salud de la Pcia de La Rioja, La Rioja, Argentina.
Nicolas KreplakMinisterio de Salud de la Pcia de Buenos Aires, Pcia de Buenos Aires, Argentina.
Marina PifanoMinisterio de Salud de la Pcia de Buenos Aires, Pcia de Buenos Aires, Argentina.
Gabriela BarbasMinisterio de Salud de la Pcia de Córdoba, Córdoba, Argentina.
Analía RearteMinisterio de Salud de la Nación, Buenos Aires, Argentina.
Carla VizzottiMinisterio de Salud de la Nación, Buenos Aires, Argentina.
Juan M CastelliMinisterio de Salud de la Nación, Buenos Aires, Argentina. Electronic address: jcastelli@msal.gov.ar.
Jorge GeffnerINBIRS-CONICET, Facultad de Medicina UBA, Buenos Aires, Argentina. Electronic address: jorgegeffner@gmail.com.
Andrea V GamarnikFundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina. Electronic address: agamarnik@leloir.org.ar.
Ministerio de Salud · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARMinisterio de Salud - Provincia de Buenos Aires · ARUniversidad Nacional de La Plata · ARFundación Instituto Leloir · ARInstituto de Investigaciones Biomédicas en Retrovirus y Sida · ARNational University of General San Martín · ARHospital Zonal General De Agudos Descentralizado "Evita Pueblo" · ARNational University of Misiones · AR

Funding

Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)U19AI168631 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Viviana A Simon · 2022 to 2026
$14.4M
MECHANISMS OF DENGUE VIRUS GENOME ENCAPSIDATION AND UNCOATINGR01AI095175 · NIAID · FUNDACION INSTITUTO LELOIR · PI GAMARNIK, ANDREA · 2011 to 2020
$1.0M
NIAID NIH HHS R01 AI095175NIAID NIH HHS U19 AI168631
6 · The paper itself

Abstract

Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase vaccination coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about the combination of these platforms with other vaccines widely used in developing countries, such as BBIBP-CorV and Sputnik V. Here, we assess the immunogenicity and reactogenicity of 15 vaccine combinations in 1,314 participants. We evaluate immunoglobulin G (IgG) anti-spike response and virus neutralizing titers and observe that a number of heterologous vaccine combinations are equivalent or superior to homologous schemes. For all cohorts in this study, the highest antibody response is induced by mRNA-1273 as the second dose. No serious adverse events are detected in any of the schedules analyzed. Our observations provide rational support for the use of different vaccine combinations to achieve wide vaccine coverage in the shortest possible time.

Indexed as

COVID-19Viral Vaccines2019-nCoV Vaccine mRNA-1273Antibodies, ViralHumansImmunizationRNA, MessengerSARS-CoV-2Vaccination2019-nCoV Vaccine mRNA-1273Antibodies, ViralRNA, MessengerViral VaccinesAd5-nCoVBBIBP-CorVChAdOx1-Sheterologous vaccinationhumoral responsemRNA-1273neutralizing antibodiesOmicron variantSARS-CoV-2Sputnik V

Identifiers

PMID35926505
PMCPMC9346506
OpenAlexW4289550659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.