Evidence map›Paper›PMID 35926031›Full record

ArticleScience (New York, N.Y.)2022

Carbene reactivity from alkyl and aryl aldehydes.

Lumin Zhang, Bethany M DeMuynck, Alyson N Paneque, Joy E Rutherford, David A Nagib

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Iron-Catalyzed Cyclopropanation of Allenes Using Unactivated Alkyl Sulfonium Salts.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Photo-Stitching of Nitroalkanes via Cross-Denitrative Olefination.Journal of the American Chemical Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lumin ZhangDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-3371-6817
Bethany M DeMuynck *Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Alyson N Paneque *Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Joy E Rutherford *Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
David A NagibDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-2275-6381

Funding

Radical Chaperones to Harness Remote, Selective C-H Functionalization MechanismsR35GM119812 · NIGMS · OHIO STATE UNIVERSITY · PI NAGIB, DAVID A · 2016 to 2025
$4.0M
The biodemography of early adversity: social behavioral processes in a wild animal model.R01AG053308 · NIA · DUKE UNIVERSITY · PI ALBERTS, SUSAN C. · 2018 to 2022
$2.2M
NIA NIH HHS R01 AG053308NIGMS NIH HHS R35 GM119812
6 · The paper itself

Abstract

Carbenes are highly enabling reactive intermediates that facilitate a diverse range of otherwise inaccessible chemistry, including small-ring formation and insertion into strong σ bonds. To access such valuable reactivity, reagents with high entropic or enthalpic driving forces are often used, including explosive (diazo) or unstable (

Identifiers

PMID35926031
PMCPMC9439075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.