ArticleScience (New York, N.Y.)2022
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Pooled it
- Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.Journal of advanced research · 2026Article
- Repeated intravesical platelet-rich plasma injections alleviate symptoms via T-cell modulation and mitochondrial dysfunction in non-ulcer interstitial cystitis/bladder pain syndrome.Scientific reports · 2026Article
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection.Nature immunology · 2026Article
- Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Identification and characterization of dietary antigens in oral tolerance.Science immunology · 2026Article
- Microplastics and Nanoplastics Cause Thyroid Dysfunction in Adolescent Mice through the Intestinal Microbiota-Mediated Hypothalamus-Pituitary-Thyroid Axis.Environment & health (Washington, D.C.) · 2026Article
- A novel CD112-derived peptide targeting gut-primed neutrophils to attenuate deadly hepatic injury.Molecular medicine (Cambridge, Mass.) · 2026Article
- Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria.bioRxiv : the preprint server for biology · 2026Article
- Luohuazizhu Granules Alleviate Symptoms of Ulcerative ColitisCombinatorial chemistry & high throughput screening · 2026Article
- Microbiota transplant therapy in inflammatory bowel disease: advances and mechanistic insights.Gut microbes · 2025Review
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- NIR-controlled photothermal intelligent nanozyme synergizes catalysis and gas therapy for multidimensional treatment of inflammatory bowel disease.Journal of nanobiotechnology · 2025Article
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis.Nature communications · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Proinflammatory macrophages transporting gut-derived bacterial DNA drive autoimmune arthritis in spondyloarthropathy.JCI insight · 2025Article
- Characteristics of the microbiota in the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.World journal of pediatrics : WJP · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 1 country.
Djenet BousbaineMicrobiology Graduate Program, Massachussetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID 0000-0003-2683-9544
Laura I FischProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0529-3186
Mariya London *Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9712-0070
Preksha BhagchandaniProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-9708-5896
Tiago B Rezende de CastroLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-0359-0611
Mark MimeeCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0002-3083-2671
Scott OlesenCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0001-5400-4945
Bernardo S ReisLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-6841-116X
David VanInsbergheMicrobiology Graduate Program, Massachussetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID 0000-0002-1933-8103
Juliana BortolattoLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Mathilde PoyetCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0001-6905-9017
Ross W ChelohaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-9871-8333
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-0987-405X
Jingjing LingProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Aaron GuptaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3630-3663
Timothy K LuCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0002-3918-8923
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0001-7013-2250
Eric J AlmCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0001-8294-9364
James J MoonCenter for Immunology and Inflammatory Diseases and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8246-931X
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8807-348X
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-0000-0452
Hidde L PloeghProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-1090-6071
Angelina M BilateCenter for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.ORCID 0000-0003-4575-786X
Rockefeller University · USBoston Children's Hospital · USIIT@MIT · USLa Jolla Institute for Immunology · USHoward Hughes Medical Institute · USMassachusetts General Hospital · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3MImposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodiesDP1AI150593 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PLOEGH, HIDDE L. · 2019 to 2023
$7.1MINTESTINAL REGULATION OF ThPOK EXPRESSION AND CD4 HELPER T CELL FUNCTIONR01DK093674 · NIDDK · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida · 2013 to 2026
$7.0MQuantifying Cell-Cell Interactions in the Immune System by Trans-Synaptic LabelingDP1AI144248 · NIAID · ROCKEFELLER UNIVERSITY · PI VICTORA, GABRIEL D · 2018 to 2022
$5.9MIntestinal surveillance by intraepithelial lymphocytesR01DK113375 · NIDDK · ROCKEFELLER UNIVERSITY · PI Semir Beyaz, Daniel S Mucida · 2017 to 2026
$5.5MSortase-mediated protein engineering for the study of host-pathogen interactionsR01AI087879 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI PLOEGH, HIDDE L. · 2010 to 2019
$4.5MNeuro-immune interactions at the intestinal surfaceR01DK126407 · NIDDK · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida · 2020 to 2026
$3.9MFunctional mapping of enteric-associated neuronsR01DK116646 · NIDDK · ROCKEFELLER UNIVERSITY · PI MUCIDA, DANIEL S · 2017 to 2021
$2.1MT cell Tolerance to Enteric Commensal BacteriaR01DK126910 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2021 to 2024
$2.0MCD4+ T cell Tolerance to Enteric Commensal BacteriaR21AI124143 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2017 to 2018
$448kNIAID NIH HHS DP1 AI144248NIAID NIH HHS DP1 AI150593NIAID NIH HHS R01 AI087879NIAID NIH HHS R21 AI124143NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK093674NIDDK NIH HHS R01 DK113375NIDDK NIH HHS R01 DK116646NIDDK NIH HHS R01 DK126407NIDDK NIH HHS R01 DK126910
Abstract
The microbiome contributes to the development and maturation of the immune system. In response to commensal bacteria, intestinal CD4
Indexed as
Bacteroidetesbeta-N-AcetylhexosaminidasesCD4-Positive T-LymphocytesColitisIntestinal MucosaAnimalsCD8 AntigensDisease Models, AnimalMiceMice, Inbred C57BLbeta-N-AcetylhexosaminidasesCD8 Antigens
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.