ArticlePLoS biology2022
Comprehensive analysis of locomotion dynamics in the protochordate Ciona intestinalis reveals how neuromodulators flexibly shape its behavioral repertoire.
Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Embodied postural dynamics underlie behavioral diversity in a benthic sessile chordate.iScience · 2026Article
- Development and circuitry of the tunicate larval Motor Ganglion, a putative hindbrain/spinal cord homolog.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Reaping the benefits of liquid handlers for high-throughput gene expression profiling in a marine model invertebrate.BMC biotechnology · 2024Article
- Sensory cells in tunicates: insights into mechanoreceptor evolution.Frontiers in cell and developmental biology · 2024Review
- Using CRISPR/Cas9 to identify genes required for mechanosensory neuron development and function.Biology open · 2023Article
- Transitions of motor neuron activities duringFrontiers in cell and developmental biology · 2023Article
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Authors and funding
5 authors.
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Abstract
Vertebrate nervous systems can generate a remarkable diversity of behaviors. However, our understanding of how behaviors may have evolved in the chordate lineage is limited by the lack of neuroethological studies leveraging our closest invertebrate relatives. Here, we combine high-throughput video acquisition with pharmacological perturbations of bioamine signaling to systematically reveal the global structure of the motor behavioral repertoire in the Ciona intestinalis larvae. Most of Ciona's postural variance can be captured by 6 basic shapes, which we term "eigencionas." Motif analysis of postural time series revealed numerous stereotyped behavioral maneuvers including "startle-like" and "beat-and-glide." Employing computational modeling of swimming dynamics and spatiotemporal embedding of postural features revealed that behavioral differences are generated at the levels of motor modules and the transitions between, which may in part be modulated by bioamines. Finally, we show that flexible motor module usage gives rise to diverse behaviors in response to different light stimuli.
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