ArticleProceedings of the National Academy of Sciences of the United States of America2022
A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 26 citations in OpenAlex.
- Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses.bioRxiv : the preprint server for biology · 2026Article
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Top-down modulation in canonical cortical circuits with short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Concurrent Encoding of Sequence Predictability and Event-Evoked Prediction Error in Unfolding Auditory Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.Nature communications · 2022Article
- A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Diverse interneuron subtypes shape sensory processing in mature cortical circuits. During development, sensory deprivation evokes powerful synaptic plasticity that alters circuitry, but how different inhibitory subtypes modulate circuit dynamics in response to this plasticity remains unclear. We investigate how deprivation-induced synaptic changes affect excitatory and inhibitory firing rates in a microcircuit model of the sensory cortex with multiple interneuron subtypes. We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together. To explain the experimentally observed independent modulation, whereby one firing rate increases and the other decreases, requires strong feedback from a second interneuron subtype (somatostatin-expressing [SST]). Our model applies to the visual and somatosensory cortex, suggesting a general mechanism across sensory cortices. Therefore, we provide a mechanistic explanation for the differential role of interneuron subtypes in regulating firing rates, contributing to the already diverse roles they serve in the cortex.
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