Evidence map›Paper›PMID 35925737›Full record

ArticleNeuropsychology2023

Cognitive domain harmonization and cocalibration in studies of older adults.

Shubhabrata Mukherjee, Seo-Eun Choi, Michael L Lee, Phoebe Scollard, Emily H Trittschuh, Jesse Mez, Andrew J Saykin, Laura E Gibbons, R Elizabeth Sanders, Andrew F Zaman and 11 more

Abstract read
In one paragraph

Article in Neuropsychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Sex-specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  10. Hypertension acts together with Aβ pathology in late-life to promote memory loss.The journal of prevention of Alzheimer's disease · 2026
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  11. Epigenetic aging in Alzheimer's disease: Relation to proteome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  12. Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  14. Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  18. Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. Multimodal axes reveal individualized amyloid-medRxiv : the preprint server for health sciences · 2026
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  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shubhabrata MukherjeeDepartment of Medicine, University of Washington.ORCID 0000-0003-2522-2884
Seo-Eun ChoiDepartment of Medicine, University of Washington.
Michael L LeeDepartment of Medicine, University of Washington.
Phoebe ScollardDepartment of Medicine, University of Washington.
Emily H TrittschuhDepartment of Psychiatry and Behavioral Sciences, University of Washington.
Jesse MezDepartment of Neurology, Boston University School of Medicine.
Andrew J SaykinDepartment of Radiology and Imaging Services, Indiana Alzheimer's Disease Research Center, Indiana University.
Laura E GibbonsDepartment of Medicine, University of Washington.
R Elizabeth SandersDepartment of Medicine, University of Washington.
Andrew F ZamanJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine.
Merilee A TeylanNational Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington.
Walter A KukullNational Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center.ORCID 0000-0002-0072-9817
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center.
Andrea Z LacroixDepartment of Epidemiology, University of California San Diego.
Eric B LarsonKaiser Permanente Washington Health Research Institute.
Michael CuccaroJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine.
Shannon MercadoVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center.
Logan DumitrescuVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center.ORCID 0000-0002-3377-7014
Paul K CraneDepartment of Medicine, University of Washington.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Paul S. Aisen · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
NIA NIH HHS K25 AG055620NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG029672NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG073439NIA NIH HHS R43 AG042904NIA NIH HHS R44 AG042904NIA NIH HHS RF1 AG022018NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NINDS NIH HHS RF1 NS115268
6 · The paper itself

Abstract

objectiveStudies use different instruments to measure cognitirating cognitive tests permit direct comparisons of individuals across studies and pooling data for joint analyses.

methodWe began our legacy item bank with data from the Adult Changes in Thought study (

resultsPrestatistical harmonization steps such qualitative and quantitative assessment of granular cognitive items and evaluating factor structure are important steps when trying to cocalibrate cognitive scores across studies. We have cocalibrated cognitive data and derived scores for four domains for 76,723 individuals across 10 studies.

conclusionsWe have implemented a large-scale effort to harmonize and cocalibrate cognitive domain scores across multiple studies of cognitive aging. Scores on the same metric facilitate meta-analyses of cognitive outcomes across studies or the joint analysis of individual data across studies. Our systematic approach allows for cocalibration of additional studies as they become available and our growing item bank enables robust investigation of cognition in the context of aging and dementia. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

Alzheimer DiseaseCognition DisordersCognitive DysfunctionAgedCognitionExecutive FunctionHumansNeuropsychological Tests

Identifiers

PMID35925737
PMCPMC9898463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.