Evidence map›Paper›PMID 35925531›Full record

Trial reportJournal of neuro-oncology2022

Baseline characteristics of adults with neurofibromatosis enrolled on a psychosocial randomized controlled trial.

Nathan S Fishbein, Ana-Maria Vranceanu, Ryan A Mace

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03406208 (Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03406208 nacompletednot on this map

Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing

TypeinterventionalSponsorMassachusetts General HospitalRan2017 to 2022Enrolled228ConditionsNeurofibromatoses, Neurofibromatosis 1, Neurofibromatosis 2, SchwannomatosisArmsStress and Symptom Management Program 1, Stress and Symptom Management Program 2
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nathan S FishbeinIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Ana-Maria VranceanuIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Ryan A MaceIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA. rmace@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-5738-8606
Harvard University · USMassachusetts General Hospital · US

Funding

U.S. Department of Defense W81XWH-17-1-0121
6 · The paper itself

Abstract

purposeNeurofibromatosis (NF) is an incurable genetic neurological condition. Psychosocial interventions that promote resiliency are a promising approach to address the high emotional distress and low quality of life (QoL) associated with NF. However, no studies have examined the psychosocial needs of treatment-seeking adults with NF. Our goal was to explore, using data from the largest efficacy trial of a psychosocial intervention for NF, differences in QoL, emotional distress, resiliency, and pain-related outcomes compared to other chronic medical populations and within subtypes (NF1, NF2, schwannomatosis; SCHW).

methodsEnrolled participants (N = 228) were geographically diverse adults with NF and elevated stress. We performed secondary analysis on baseline measures of QoL, emotional distress, resiliency, and pain-related outcomes. We reported descriptive statistics and normative comparisons to understand the psychosocial characteristics of the overall sample and performed between-group analyses to explore differences within NF type.

resultsOur sample endorsed worse QoL, emotional distress, resilience, and pain-related outcomes than similar chronic illness populations. Within NF types, participants with NF1 reported lower QoL and resilience compared to those with NF2. Participants with SCHW reported higher pain intensity than those with NF1. Participants with SCHW reported higher pain interference and lower physical QoL compared to those with NF1 and NF2.

conclusionsOur findings support the urgent need for psychosocial interventions targeting deficits in QoL, emotional distress, resilience, and pain-related outcomes in adults with NF. We recommend efforts to enhance sample diversity, prepare clinicians to provide high-levels of support, and attune skills training to each NF type.

trial registrationClinicalTrials.gov NCT03406208; https://clinicaltrials.gov/ct2/show/NCT03406208 (Archived by WebCite at http://www.webcitation.org/72ZoTDQ6h ).

Indexed as

NeurilemmomaNeurofibromatosesNeurofibromatosis 1Neurofibromatosis 2AdultHumansPainQuality of LifeBaseline characteristicsEmotional distressNeurofibromatosisPsychosocialQuality of life

Identifiers

PMID35925531
OpenAlexW4289766797

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.