Evidence map›Paper›PMID 35925530›Full record

ArticleJournal of neuro-oncology2022

Preservation of endocrine function after Ommaya reservoir insertion in children with cystic craniopharyngioma.

Laura-Nanna Lohkamp, Abhaya V Kulkarni, James M Drake, James T Rutka, Peter B Dirks, Michael Taylor, George M Ibrahim, Jill Hamilton, Ute K Bartels

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Visual outcomes after treatment of craniopharyngioma in children: A systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura-Nanna LohkampDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Abhaya V KulkarniDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
James M DrakeDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
James T RutkaDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Peter B DirksDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Michael TaylorDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
George M IbrahimDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jill HamiltonDivision of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Ute K BartelsDivision of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G2J9, Canada. Ute.Bartels@sickkids.ca.
University of Toronto · CAHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChildren with craniopharyngiomas (CP) can experience significant morbidities caused by extensive surgery and/or radiation. Ommaya reservoir insertion (ORI) into cystic CP represents a minimally invasive approach allowing immediate decompression and aims to avoid additional injuries. The purpose of this study was to determine the surgical outcome and relevance of upfront ORI (± intracystic treatment) for preservation of endocrine function.

methodsWe performed a retrospective chart review of children with CP treated at the Hospital for Sick Children between 01/01/2000 and 15/01/2020. Endocrine function was reviewed at the time of initial surgery and throughout follow-up. New endocrinological deficits related to the index procedure were defined as immediate failure (IF), whereas postoperative duration of endocrinological stability (ES) was analyzed using the Kaplan-Meier method. The rate of IF and ES was compared between the treatment groups.

resultsSeventy-nine patients were included and had a median age of 8.3 years (range 2.1-18.0 years); 31 were males. Fifty-three patients with upfront surgical treatment, including 29 ORI and 24 gross total or partial resections had sufficient endocrinological follow-up data. Endocrine dysfunction occurring immediately after the index procedure (IF) was observed in 15 patients (62.5%) in the resection group compared to two patients (6.8%) in the ORI group, odds ratio: 0.05 (CI: 0.01-0.26, p < 0.0001). Excluding those with immediate endocrinological deficits, mean ES after ORI was 19.4 months (CI: 11.6-34.2), compared to 13.4 months (CI:10.6-NA) after surgical resection.

conclusionsEndocrine function was preserved in patients with upfront ORI (± intracystic treatment), which was confirmed as a minimally invasive procedure with an overall low morbidity profile.

Indexed as

CraniopharyngiomaPituitary NeoplasmsAdolescentChildChild, PreschoolFemaleHumansMaleRetrospective StudiesTreatment OutcomeCraniopharyngiomaCysticEndocrine functionOmmaya reservoirResection

Identifiers

PMID35925530
OpenAlexW4289731172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.