Evidence map›Paper›PMID 35925389›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Molecular subtyping of gastroesophageal dysplasia heterogeneity according to TCGA/ACRG classes.

Valentina Angerilli, Gianmaria Pennelli, Francesca Galuppini, Stefano Realdon, Alberto Fantin, Edoardo Savarino, Fabio Farinati, Luca Mastracci, Claudio Luchini, Matteo Fassan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Advances in the molecular subtyping of gastric cancer.World journal of surgical oncology · 2026
    Review
  2. Research advances in the molecular classification of gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Valentina AngerilliDepartment of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, via Gabelli 61, 35121, Padua, Italy.
Gianmaria PennelliDepartment of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, via Gabelli 61, 35121, Padua, Italy.
Francesca GaluppiniDepartment of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, via Gabelli 61, 35121, Padua, Italy.
Stefano RealdonIstituto Oncologico Veneto-IOV-IRCCS, Padua, Italy.
Alberto FantinIstituto Oncologico Veneto-IOV-IRCCS, Padua, Italy.
Edoardo SavarinoDepartment of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, Padua, Italy.
Fabio FarinatiDepartment of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, Padua, Italy.
Luca MastracciDepartment of Surgical Science and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy.
Claudio LuchiniDepartment of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
Matteo FassanDepartment of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, via Gabelli 61, 35121, Padua, Italy. matteo.fassan@unipd.it.ORCID http://orcid.org/0000-0001-6515-5482
University of Padua · ITIstituto Oncologico Veneto · ITUniversity of Genoa · IT

Funding

Associazione Italiana per la Ricerca sul Cancro 22759Università degli Studi di Verona NET-2016-02363853
6 · The paper itself

Abstract

Gastric adenocarcinoma has recently been classified into several subtypes on the basis of molecular profiling, which has been successfully reproduced by immunohistochemistry (IHC) and in situ hybridization (ISH). A series of 73 gastroesophageal dysplastic lesions (37 gastric dysplasia and 36 Barrett dysplasia; 44 low-grade dysplasia and 29 high-grade dysplasia) was investigated for mismatch repair proteins, E-cadherin, p53, and EBER status, to reproduce The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) molecular clustering. Overall, the dysplastic lesions were classified as follows: according to TCGA classification, EBV, 0/73 (0%), MSI, 6/73 (8.2%), GS, 4/73 (5.5%), CIN, 63/73 (86.3%); according to ACRG molecular subtyping, MSI, 6/73 (8.2%), MSS/EMT, 4/73 (5.5%), MSS/TP53

Indexed as

AdenocarcinomaStomach NeoplasmsBiomarkersCadherinsHumansHyperplasiaTumor Suppressor Protein p53BiomarkersCadherinsTumor Suppressor Protein p53Gastroesophageal cancerGastroesophageal dysplasiaMolecular classification

Identifiers

PMID35925389
PMCPMC9534804
OpenAlexW4289745395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.