ReviewPathologie (Heidelberg, Germany)2022
[Drug-induced bone marrow changes].
Review in Pathologie (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- [Real-world experience with aflibercept 8 mg for treatment of neovascular age-related macular degeneration after 12 months].Die Ophthalmologie · 2026Article
- Case Report: Qizhi Yishen Capsule-induced bone marrow granulomas and severe myelosuppression.Frontiers in allergy · 2026Article
- [Bone marrow histology of cytopenias : Contribution to hematological differential diagnosis].Pathologie (Heidelberg, Germany) · 2024Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Cytomorphological and histomorphological analysis of bone marrow cells in cases with abnormal production of blood cells must always take the unwanted side effects of drugs into account. Drugs can affect single lineages or the complete bone marrow. Besides quantitative phenomena consisting of hypoplasia or hyperplasia, maturation of blood cells may be disturbed. Disturbances encompass left shifts, which may be extreme, or imitate states of vitamin deficiency and atypia occurring in myelodysplastic syndromes (MDS). In addition, all bone marrow lineages may be affected, simulating aplastic anemia. The spectrum of causative drugs is very broad, and the induced changes are generally not specific enough to identify the underlying drug culprit, which requires knowledge of the patient's drug history. Cytotoxic drugs applied in oncology can induce MDS with an average latency of 2-6 years, or even shorter in the case of drugs interfering with DNA repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.