Evidence map›Paper›PMID 35925203›Full record

Trial reportInternational urogynecology journal2023

The effect of oral medications on fMRI brain activation: A randomized, double blind, controlled pilot trial of older women with overactive bladder.

Rachel A High, Zhaoyue Shi, Jill M Danford, Erin T Bird, Christof Karmonik, Rose Khavari

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Rachel A HighDell Medical School, Department of Women's Health, University of Texas at Austin, 1301 West 38th Street Suite 705, Austin, TX, 78705, USA. Rachel.high@austin.utexas.edu.ORCID 0000-0002-3717-0893
Zhaoyue ShiDepartment of Surgery, Division of Urology, Baylor Scott and White Health, Temple, TX, USA.
Jill M DanfordHouston Methodist Research Institute Translational imaging center, Houston, TX, USA.
Erin T BirdHouston Methodist Research Institute Translational imaging center, Houston, TX, USA.
Christof KarmonikDepartment of Surgery, Division of Urology, Baylor Scott and White Health, Temple, TX, USA.
Rose KhavariDepartment of Urology, Houston Methodist Hospital, Houston, TX, USA.
Baylor Scott & White Health · USHouston Methodist · USMethodist Hospital · USThe University of Texas at Austin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimObservational studies have associated oral anticholinergic medications for overactive bladder (OAB) with cognitive impairment. This is the first pilot trial to compare the effects of two classes of OAB medications on brain activity in women. We evaluated the effect of anticholinergic versus non-anticholinergic (Non-Ach) interventions on regional brain activation during a cognitive task.

methodsTwelve cognitively normal women seeking OAB therapy were recruited to a randomized, double-blind, parallel, controlled pilot trial. Whole-brain regional activity at baseline and 29 ± 1 days postintervention was assessed with functional magnetic resonance imaging during a working memory task. Average activation strength by region was compared after anticholinergic, beta-3 agonist, or placebo. Two-way ANOVA compared effects of group and time on average activation strength in anticholinergic versus Non-Ach (beta-3 agonists or placebo) groups.

resultsThe mean (SD) age and body mass index of 12 women were 61 (7) years and 36 (7) kg/m

conclusionActivation strength in brain regions underlying working memory was lower over time, and recognition scores improved. A powered trial is needed to adequately evaluate for differential effects of OAB oral medications on regional brain activation.

Indexed as

Cholinergic AntagonistsMagnetic Resonance ImagingUrinary Bladder, OveractiveAgedBrainFemaleHumansPilot ProjectsCholinergic AntagonistsAnticholinergicBeta agonistCognitionIncontinenceMemoryOveractive bladder

Identifiers

PMID35925203
PMCPMC9362589
OpenAlexW4289836965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.