Evidence map›Paper›PMID 35925037›Full record

Trial reportNeurorehabilitation and neural repair2022

Barriers to Enrollment in Post-Stroke Brain Stimulation in a Racially and Ethnically Diverse Population.

Timea Hodics, Leonardo G Cohen, John C Pezzullo, Karen Kowalske, Alexander W Dromerick

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01007136 (TDCS-enhanced Stroke Recovery and Cortical Reorganization), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01007136 naterminatednot on this map

TDCS-enhanced Stroke Recovery and Cortical Reorganization

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2009 to 2014Enrolled62ConditionsIschemic StrokeArmstDCS, Sham tDCS
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Timea HodicsDepartment of Neurology and Neurotherapeutics, 12334University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8957-7807
Leonardo G CohenHuman Cortical Physiology and Stroke Neurorehabilitation Section, National Institutes of Health, 35046National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA.
John C PezzulloDepartment of Medicine, 8368Georgetown University Medical Center, Washington, DC, USA.
Karen KowalskeDepartment of Physical Medicine and Rehabilitation, 12334University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alexander W DromerickDepartment of Rehabilitation Medicine and Neurology, MedStar National Rehabilitation Hospital, Washington, DC, USA.
Georgetown University · USMedStar National Rehabilitation Hospital · USMethodist Hospital · USNational Institutes of Health · USThe University of Texas Southwestern Medical Center · US

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
TDCS-Enhanced Stroke Recovery and Cortical ReorganizationK23HD050267 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI HODICS, TIMEA M · 2007 to 2011
$831k
NICHD NIH HHS K23 HD050267
6 · The paper itself

Abstract

background and purposeBrain stimulation is an adjuvant strategy to promote rehabilitation after stroke. Here, we evaluated the influence of inclusion/exclusion criteria on enrollment in a transcranial direct current stimulation (tDCS) trial in the context of a racially/ethnically diverse acute stroke service at University of Texas Southwestern (UTSW).

methods3124 (59.7 ± 14.5 years) racially/ethnically diverse (38.4% non-Hispanic white, (W), Hispanic (H) 22%, African American (AA) 33.5%, Asian (A) 2.3%) patients were screened in the acute stroke service at UTSW. Demographics, stroke characteristics, and reasons for exclusion were recorded prospectively.

results2327 (74.5%) patients had a verified stroke. Only 44 of them (1.9%) were eligible. Causes for exclusion included in order of importance: (1) magnitude of upper extremity (UE) motor impairment, (2) prior strokes (s), (3) hemorrhagic stroke, (4) psychiatric condition or inability to follow instructions, and (5) old age, of these (2) and (4) were more common in AA patients but not in other minorities. 31 of the 44 eligible individuals were enrolled (W 1.68%, H 1.37%, AA .77%, A 3.774%). 90.5% of verified stroke patients did not exhibit contraindications for stimulation.

conclusions3 main conclusions emerged: (a) The main limitations for inclusion in brain stimulation trials of motor recovery were magnitude of UE motor impairments and stroke lesion characteristics, (b) most stroke patients could be stimulated with tDCS without safety concerns and (c) carefully tailored inclusion criteria could increase diversity in enrollment.Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT01007136.

Indexed as

StrokeStroke RehabilitationTranscranial Direct Current StimulationBrainHumansRecovery of FunctionUpper Extremitybraindemographicsdisparitiesmotorstroketranscranial direct current stimulation

Identifiers

PMID35925037
PMCPMC9509403
OpenAlexW4289781013

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.