Evidence map›Paper›PMID 35924898›Full record

ArticleInfection and immunity2022

Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection.

Karina K Sanchez, Katia Troha, Andre Mu, Samuel E Redford, Justin L McCarville, Arianna Insenga, Sarah Stengel, Yujung Michelle Lee, Janelle S Ayres

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Karina K Sanchez *Molecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Katia Troha *Molecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.ORCID 0000-0001-9389-4952
Andre MuMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Samuel E RedfordMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Justin L McCarvilleMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Arianna InsengaMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Sarah StengelMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Yujung Michelle LeeMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.
Janelle S AyresMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA.ORCID 0000-0002-0809-2494
Salk Institute for Biological Studies · US

Funding

Host-microbe interactions: Harnessing co-evolution to treat diseaseDP1AI144249 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2018 to 2022
$6.7M
Tolerance defenses in host-microbiota interactionsR01AI114929 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2015 to 2025
$4.9M
NIAID NIH HHS DP1 AI144249NIAID NIH HHS R01 AI114929
6 · The paper itself

Abstract

To combat infections, hosts employ a combination of antagonistic and cooperative defense strategies. The former refers to pathogen killing mediated by resistance mechanisms, while the latter refers to physiological defense mechanisms that promote host health during infection independent of pathogen killing, leading to an apparent cooperation between the host and the pathogen. Previous work has shown that Leptin, a pleiotropic hormone that plays a central role in regulating appetite and energy metabolism, is indispensable for resistance mechanisms, while a role for Leptin signaling in cooperative host-pathogen interactions remains unknown. Using a mouse model of Yersinia pseudotuberculosis (

Indexed as

Yersinia pseudotuberculosisYersinia pseudotuberculosis InfectionsHost-Pathogen InteractionsHumansLeptinLipidsLeptinLipidsdisease tolerancehost-pathogen cooperationLeptinlipid utilizationphysiological damageYersinia pseudotuberculosis

Identifiers

PMID35924898
PMCPMC9476980
OpenAlexW4289844153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.