Evidence map›Paper›PMID 35924442›Full record

ArticleThe Journal of infectious diseases2022

Association Between Prolonged Shedding of Zika Virus in Human Semen and Male Reproductive Tract Inflammation.

Megan B Vogt, Erin M McDonald, Mark Delorey, Paul S Mead, Sarah A Hook, Alison F Hinckley, Stephen R Werre, Aaron C Brault, Nisha K Duggal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. CD8Npj viruses · 2024
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Megan B VogtDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Erin M McDonaldCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Mark DeloreyCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Paul S MeadCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Sarah A HookCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Alison F HinckleyCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Stephen R WerreDepartment of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Aaron C BraultCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Fort Collins, Colorado, USA.
Nisha K DuggalDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Centers for Disease Control and Prevention · USVirginia Tech · USNational Center for Emerging and Zoonotic Infectious Diseases · USVirginia–Maryland College of Veterinary Medicine · US

Funding

Determinants of prolonged Zika virus shedding in semenR21AI142504 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DUGGAL, NISHA · 2019 to 2020
$425k
NIAID NIH HHS R21 AI142504
6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that causes congenital defects. Sexual transmission of ZIKV was confirmed in a recent epidemic; however, mechanisms behind ZIKV infection and persistence in the male reproductive tract (MRT) are unknown. Previously, we found that approximately 33% of men with symptomatic ZIKV infections shed ZIKV RNA in semen, and some men shed ZIKV RNA for >3 months. Here, we evaluated the semen of 49 ZIKV-infected men to identify immune factors correlating with long-term ZIKV shedding in semen and ZIKV-infected cell types in semen. We found that prolonged ZIKV RNA shedding in semen was associated with MRT inflammation, indicated by higher leukocyte counts and inflammatory cytokine concentrations in semen of long-term versus short-term shedders. In addition, we found ZIKV RNA in seminal leukocytes and epithelial cells. This study of human semen from ZIKV-infected men provides critical insights into the effects of ZIKV on MRT health.

Indexed as

Zika VirusZika Virus InfectionAnimalsCytokinesHumansInflammationMaleRNASemenVirus SheddingCytokinesRNAflow cytometryinflammationleukocytospermiamale reproductive tractsexual transmissionZika virus

Identifiers

PMID35924442
PMCPMC10233496
OpenAlexW4289754975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.