Evidence map›Paper›PMID 35924373›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Impact of the Post-Thrombotic Syndrome on the Arterial Wall of the Lower Limbs.

Mingshu Lu, Xiangbin Qi, Jingpeng Bi, Yunhui Li

Open access · goldAbstract read
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In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mingshu LuDepartment of Vascular Surgery, People's Hospital Affiliated to Shandong First Medical University, Jinan city, Shandong province, China.ORCID https://orcid.org/0000-0003-2002-7940
Xiangbin QiDepartment of Medical Imaging, People's Hospital Affiliated to Shandong First Medical University, Jinan city, Shandong province, China.
Jingpeng BiDepartment of Vascular Surgery, People's Hospital Affiliated to Shandong First Medical University, Jinan city, Shandong province, China.
Yunhui LiDepartment of Vascular Surgery, People's Hospital Affiliated to Shandong First Medical University, Jinan city, Shandong province, China.
Shandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDeep vein thrombosis of the lower limbs is a common disease in vascular surgery. Approximately 20-50% of deep vein thrombosis patients develop post-thrombotic syndrome, which can severely affect the patient's quality of life. However, the precise science of the pathophysiology of the progression of the post-thrombotic syndrome remains unclear. Studies have demonstrated that patients with post-thrombotic syndrome of the lower limbs have impaired arterial wall endothelial function. Nevertheless, there is little research on the different impacts of post-thrombotic syndrome on the arterial wall endothelial function between the affected limbs and the healthy limbs. This study aims to assess this difference.

methodsA total of 60 patients treated for the post-thrombotic syndrome of the lower limbs were included. The flow-mediated dilation (FMD%) and nitroglycerin-mediated dilation (NMD%) were measured to assess the different endothelial function alterations of the common femoral arterial wall between the affected limb and the healthy limb.

resultsNo significant differences in the common femoral artery diameter between the affected limbs and the healthy limbs were discovered (8.94  ±  0.92 mm vs 8.75  ±  1.0 mm, P = 0.710). The flow-mediated dilation of the common femoral artery of the affected limbs were significantly lower compared to the healthy limbs (FMD%: 3.21  ±  1.07% vs 5.19  ±  1.35%, P  =  0.001). However, there was no significant difference in the nitroglycerin-mediated dilation of the common femoral artery between the affected limbs and the healthy limbs（ NMD%: 13.37  ±  1.78% versus 14.45  ±  2.14%, P = 0.083).

conclusionsOur results demonstrated the association between post-thrombotic syndrome and deteriorated endothelial functional properties of the arterial wall of the lower limbs. Endothelial dysfunction of the arteries wall was more severe in the affected lower limbs with the post-thrombotic syndrome than in the healthy limbs. The mentioned findings may partly explain the pathophysiology of the progression post-thrombotic syndrome of the lower limbs. HIGHLIGHTS: tudies have demonstrated that patients with post-thrombotic syndrome of the lower limbs have impaired arterial wall endothelial function. Our results demonstrated the endothelial dysfunction of the arteries wall was more severe in the affected lower limbs with the post-thrombotic syndrome than in the healthy limbs. Our findings may partly explain the pathophysiology of the progression post-thrombotic syndrome of the lower limbs.

Indexed as

Postthrombotic SyndromeVascular DiseasesArteriesBrachial ArteryEndothelium, VascularHumansLower ExtremityNitroglycerinQuality of LifeVasodilationNitroglycerinarterial wall endothelial functionflow-mediated dilationnitroglycerin-mediated dilationpost-thrombotic syndrome

Identifiers

PMID35924373
PMCPMC9358595
OpenAlexW4289746455

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.