ArticleFrontiers in neuroscience2022
The Atypical Effective Connectivity of Right Temporoparietal Junction in Autism Spectrum Disorder: A Multi-Site Study.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Autism and Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- EEG during dynamic facial emotion processing reveals neural activity patterns associated with autistic traits in children.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Rethinking body representations in autism across cultures.Frontiers in psychiatry · 2025Article
- EEG During Dynamic Facial Emotion Processing Reveals Neural Activity Patterns Associated with Autistic Traits in Children.bioRxiv : the preprint server for biology · 2024Article
- Abnormalities of EEG Functional Connectivity and Effective Connectivity in Children with Autism Spectrum Disorder.Brain sciences · 2023Article
- Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack.Neural plasticity · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Social function impairment is the core deficit of autism spectrum disorder (ASD). Although many studies have investigated ASD through a variety of neuroimaging tools, its brain mechanism of social function remains unclear due to its complex and heterogeneous symptoms. The present study aimed to use resting-state functional magnetic imaging data to explore effective connectivity between the right temporoparietal junction (RTPJ), one of the key brain regions associated with social impairment of individuals with ASD, and the whole brain to further deepen our understanding of the neuropathological mechanism of ASD. This study involved 1,454 participants from 23 sites from the Autism Brain Imaging Data Exchange (ABIDE) public dataset, which included 618 individuals with ASD and 836 with typical development (TD). First, a voxel-wise Granger causality analysis (GCA) was conducted with the RTPJ selected as the region of interest (ROI) to investigate the differences in effective connectivity between the ASD and TD groups in every site. Next, to obtain further accurate and representative results, an image-based meta-analysis was implemented to further analyze the GCA results of each site. Our results demonstrated abnormal causal connectivity between the RTPJ and the widely distributed brain regions and that the connectivity has been associated with social impairment in individuals with ASD. The current study could help to further elucidate the pathological mechanisms of ASD and provides a new perspective for future research.
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