Evidence map›Paper›PMID 35923912›Full record

ArticlePNAS nexus2022

Argonaute 2 modulates EGFR-RAS signaling to promote mutant

Ronald F Siebenaler, Seema Chugh, Jessica J Waninger, Vijaya L Dommeti, Carson Kenum, Malay Mody, Anudeeta Gautam, Nidhi Patel, Alec Chu, Pushpinder Bawa and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The Potential of Senescence as a Target for Developing Anticancer Therapy.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Ronald F SiebenalerMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-1583-1547
Seema ChughMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Jessica J WaningerMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Vijaya L DommetiMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Carson KenumMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Malay ModyMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Anudeeta GautamMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Nidhi PatelMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-5890-6858
Alec ChuMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Pushpinder BawaMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer HonMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Richard D SmithCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Heather CarlsonCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Xuhong CaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
John J G TesmerDepartments of Biological Sciences and Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID https://orcid.org/0000-0003-1125-3727
Sunita ShankarMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-8743-7480
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-9282-3415
University of Michigan · USHoward Hughes Medical Institute · USPurdue University West Lafayette · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1M
Exploring Precision Oncology: From Gene Fusions to lncRNAsR35CA231996 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 2018 to 2024
$6.4M
Characterization of growth factor control of Argonaute 2 and RAS interactionF30CA221011 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIEBENALER, RONALD FRANCIS · 2017 to 2019
$122k
NCI NIH HHS F30 CA221011NCI NIH HHS R35 CA231996NHLBI NIH HHS R01 HL071818NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Activating mutations in RAS GTPases drive nearly 30% of all human cancers. Our prior work described an essential role for Argonaute 2 (AGO2), of the RNA-induced silencing complex, in mutant

Indexed as

Argonaute 2EGFRHRASNRASsenescence

Identifiers

PMID35923912
PMCPMC9338400
OpenAlexW4288436694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.