Evidence map›Paper›PMID 35923855›Full record

ReviewFrontiers in cell and developmental biology2022

The structure, biosynthesis, and biological roles of fetuin-A: A review.

Endeshaw Chekol Abebe, Zelalem Tilahun Muche, Awigchew Behaile T/Mariam, Teklie Mengie Ayele, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Tadesse Asmamaw Dejenie, Misganaw Asmamaw Mengstie

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 3 pooled it
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Endeshaw Chekol AbebeDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Zelalem Tilahun MucheDepartment of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Awigchew Behaile T/MariamDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Teklie Mengie AyeleDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Melaku Mekonnen AgidewDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Muluken Teshome AzezewDepartment of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Edgeit Abebe ZewdeDepartment of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Tadesse Asmamaw DejenieDepartment of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Misganaw Asmamaw MengstieDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Debre Tabor University · ETUniversity of Gondar · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. Fetuin-A has also been demonstrated to play a crucial role in the pathogenesis of several disorders. This review mainly focuses on the structure, synthesis, and biological roles of fetuin-A. Information was gathered manually from various journals

Indexed as

biological rolesbiosynthesisfetuin-Ainflammationstructure

Identifiers

PMID35923855
PMCPMC9340150
OpenAlexW4285726434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.