ArticleFrontiers in pediatrics2022
The Epidemiology and Outcome of Biliary Atresia: Saudi Arabian National Study (2000-2018).
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 17 citations in OpenAlex.
- The Italian biliary atresia registry: Insights and lessons from the retrospective analysis of a 10-year period cohort.Journal of pediatric gastroenterology and nutrition · 2026Article
- Association of postoperative infection with early bilirubin clearance and native liver survival: a single - center retrospective cohort study.BMC pediatrics · 2026Article
- Role of Liver Biopsy in Biliary Atresia: Impact of Histological Fibrosis on Kasai Portoenterostomy Outcomes and Decision Making.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Incidence and outcome of biliary atresia in the United Arab Emirates: A multicenter national study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Article
- Experience of pediatric liver disease at a university hospital in Western Saudi Arabia.Saudi medical journal · 2025Article
- Dramatic Extrahepatic Cholestasis Improvement after Steroid Therapy.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- Syndromic variants of biliary atresia.World journal of pediatric surgery · 2025Review
- A narrative review of genes associated with liver fibrosis in biliary atresia.Translational pediatrics · 2024Review
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Clinical and laboratory features of biliary atresia and patterns of management practices: Saudi national study (2000-2018).Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Patterns and unique features of infantile cholestasis among Arabs.Frontiers in pediatrics · 2024Article
- Biliary Atresia: advances and challenges in early diagnosis and management.Jornal de pediatriaReview
- Predictors of biliary atresia outcome: Saudi National Study (2000 - 2018).Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
30 authors at 12 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The epidemiology and outcomes of biliary atresia (BA) have been well-documented in national cohorts from two main ethnicities, namely, the Asian Orientals and Caucasians, with incidence ranging from 1 in 5,000 to 1 in 9,000 live births in East Asia and 1 in 15,000 to 19,000 live births in Europe and North America. Objective: We report the first nationwide BA study outside North America, Europe, and East Asia to describe the epidemiology and outcomes of BA in Saudi Arabia. Methods: A national database of BA cases diagnosed between 2000 and 2018 was analyzed. We assessed clearance of jaundice (bilirubin <20 μmol/L) in all cases that underwent Kasai portoenterostomy (KPE). We then estimated survival using the Kaplan-Meier method with endpoints of liver transplantation (LT), death, or survival with native liver (SNL). Results: BA was diagnosed in 204 infants (106 females; 10% pre-term). The incidence of BA was 1 in 44,365, or 2.254 in 100,000 live births (range, 0.5-4 in 100,000). Polysplenia was diagnosed in 22 cases (11%). The median age at referral was 65 days. A total of 146 children (71.5%) underwent KPE at a median age of 70 days. Clearance of jaundice was achieved in 66 of the 146 (45%) infants. The 10-year SNL after KPE was 25.5%, and the overall 10-year estimated survival was 72.5%. The Kaplan-Meier survival curves for patients undergoing KPE at the age of <60, 61-90, and >90 days showed a SNL rate at 51.6, 33, and 12.5%, respectively, at 5 years ( Conclusion: The incidence rate of BA in Saudi Arabia is lower than the incidence reported elsewhere. Late referral of BA cases remains a problem in Saudi Arabia; as a result, the SNL rate was lower than reported by other national registries. Hence, national policies devoted to timely referral and earlier age at KPE are needed.
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