Evidence map›Paper›PMID 35923775›Full record

ArticleSensors & diagnostics2022

On-chip integrated graphene aptasensor with portable readout for fast and label-free COVID-19 detection in virus transport medium.

Lizhou Xu, Sami Ramadan, Bruno Gil Rosa, Yuanzhou Zhang, Tianyi Yin, Elias Torres, Olena Shaforost, Apostolos Panagiotopoulos, Bing Li, Gwilherm Kerherve and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Sensors & diagnostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 39 citations in OpenAlex.

  1. From Sensing Mechanisms to System Co-Design: Graphene-Based Sensors and Readout Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Lizhou XuDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.ORCID https://orcid.org/0000-0001-5983-4059
Sami RamadanDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Bruno Gil RosaHamlyn Centre, Imperial College London London SW7 2AZ UK.
Yuanzhou ZhangDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Tianyi YinDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Elias TorresGraphenea Semiconductor Paseo Mikeletegi 83 San Sebastián 20009 Spain.
Olena ShaforostDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Apostolos PanagiotopoulosDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.ORCID https://orcid.org/0000-0001-8542-4694
Bing LiDepartment of Brain Sciences, Imperial College London London W12 0BZ UK.
Gwilherm KerherveDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Dong Kuk KimDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.ORCID https://orcid.org/0000-0003-3463-5293
Cecilia MatteviDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.ORCID https://orcid.org/0000-0003-0005-0633
Long R JiaoDepartment of Hepatobiliary Surgery, Division of Surgery & Cancer, Imperial College London Hammersmith Hospital Campus, Du Cane Road London W12 0NN UK.
Peter K PetrovDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Norbert KleinDepartment of Materials, Imperial College London London SW7 2AZ UK l.xu@imperial.ac.uk n.klein@imperial.ac.uk.
Imperial College London · GBGraphenea (Spain) · ESHammersmith Hospital · GBUK Dementia Research Institute · GBZhejiang University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graphene field-effect transistor (GFET) biosensors exhibit high sensitivity due to a large surface-to-volume ratio and the high sensitivity of the Fermi level to the presence of charged biomolecules near the surface. For most reported GFET biosensors, bulky external reference electrodes are used which prevent their full-scale chip integration and contribute to higher costs per test. In this study, GFET arrays with on-chip integrated liquid electrodes were employed for COVID-19 detection and functionalized with either antibody or aptamer to selectively bind the spike proteins of SARS-CoV-2. In the case of the aptamer-functionalized GFET (aptasensor, Apt-GFET), the limit-of-detection (LOD) achieved was about 10

Identifiers

PMID35923775
PMCPMC9280445
OpenAlexW4285255025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.