Evidence map›Paper›PMID 35923774›Full record

ArticleSensors & diagnostics2022

Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates.

Yiran Huang, Liang Sun, Liviu M Mirica

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Sensors & diagnostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yiran HuangDepartment of Chemistry, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana IL 61801 USA mirica@illinois.edu.ORCID https://orcid.org/0000-0003-1755-9874
Liang SunDepartment of Chemistry, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana IL 61801 USA mirica@illinois.edu.ORCID https://orcid.org/0000-0002-0080-0855
Liviu M MiricaDepartment of Chemistry, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana IL 61801 USA mirica@illinois.edu.ORCID https://orcid.org/0000-0003-0584-9508
University of Illinois Urbana-Champaign · US

Funding

NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
NIGMS NIH HHS R01 GM114588
6 · The paper itself

Abstract

Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates.

Identifiers

PMID35923774
PMCPMC9280444
OpenAlexW4285310366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.