Evidence map›Paper›PMID 35923645›Full record

ArticleIJID regions2022

Molecular characterization and antimicrobial resistance of

Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Shigeki Shimada, Mayumi Nakamura, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

Open access · goldAbstract read
In one paragraph

Article in IJID regions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical and molecular characteristics of Streptococcus agalactiae bacteremia in nonpregnant adults: a single-center analysis over 16 years in Hiroshima, Japan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Article
  5. Article
  6. Group BJournal of Korean medical science · 2025
    Article
  7. A Comparative Analysis of Molecular Epidemiology and Antibiotic Resistance in Group B Streptococcus Isolated From Invasive and Noninvasive Adult Cases in Daejeon, South Korea.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Prevalence, risk factors, and serotypes of group BTherapeutic advances in infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mitsuyo KawaguchiyaDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Noriko UrushibaraDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Meiji Soe AungDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Shigeki ShimadaMommy's Clinic Chitose.
Mayumi NakamuraSapporo Clinical Laboratory, Inc., Sapporo, Japan.
Masahiko ItoSapporo Clinical Laboratory, Inc., Sapporo, Japan.
Satoshi HabaderaSapporo Clinical Laboratory, Inc., Sapporo, Japan.
Nobumichi KobayashiDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Sapporo Medical University · JPSapporo Science Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to elucidate the molecular characteristics and antimicrobial resistance of Methods: GBS isolates obtained from screening of pregnant women from 2017 to 2021 were analyzed for capsular serotype, sequence type (ST), and antimicrobial susceptibility. For levofloxacin-resistant isolates, mutations in the quinolone resistance-determining regions (QRDRs) of the Results: Seventy-six GBS isolates were recovered from 1090 women (isolation rate: 7.0%). Of the 76 isolates, serotype III (31.6%) was the most prevalent, followed by V (19.7%), Ia (17.1%), and Ib (10.5%). Among the 22 STs identified, capsular serotype III/ST335-clonal complex (CC) 19 lineage was dominant (13.2%), followed by Ia/ST23, III/ST17, and V/ST1. Levofloxacin resistance was detected in 15.8% (n=12) of all the isolates, with serotype Ib being the most common. Most levofloxacin resistant isolates belonged to serotype Ib/CC10 or serotype V/CC19, with double mutations in the QRDRs, Ser81Leu in GyrA and Ser79Phe in ParC. Conclusions: The present study indicates the prevalence of the serotype III/ST335 (CC19) lineage, and the spread of serotype Ib/CC10 and serotype V/CC19 lineages, which are responsible for levofloxacin resistance in colonizing GBS in pregnant women in Japan.

Indexed as

CC, clonal complexGBS, group B streptococcusJapanMICs, minimum inhibitory concentrationsMLST, multilocus sequence typingQRDRs, quinolone resistance-determining regionsQuinolone resistanceSequence typeSerotypeStreptococcus agalactiaeST, sequence type

Identifiers

PMID35923645
PMCPMC9340534
OpenAlexW4285499251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.