ArticleFrontiers in psychiatry2022
P300 Modulation
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic Review.Revista de neurologia · 2026Pooled it
- Comparative efficacy of non-invasive brain stimulation for attention-deficit/hyperactivity disorder: a systematic review and network meta-analysis.Frontiers in neurology · 2025Pooled it
- Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes.Frontiers in psychiatry · 2024Pooled it
- Efficacy and safety of transcranial alternating current stimulation in adults with attention deficit hyperactivity disorder: a double-blind randomized sham-controlled trial.Molecular psychiatry · 2026Trial
- Mechanisms and clinical applications of transcranial alternating current stimulation in the treatment of neuropsychiatric disorders: Current evidence and future directions.Chinese medical journal · 2026Review
- Advanced machine learning techniques reveal multidimensional EEG abnormalities in children with ADHD: a framework for automatic diagnosis.Frontiers in psychiatry · 2025Article
- Aligning Event-Related Potentials with Transcranial Alternating Current Stimulation for Modulation-a Review.Brain topography · 2024Review
- Differences in Children and Adolescents with Depression before and after a Remediation Program: An Event-Related Potential Study.Brain sciences · 2024Article
- Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review.European archives of psychiatry and clinical neuroscience · 2024Review
- Article
- Alpha modulation via transcranial alternating current stimulation in adults with attention-deficit hyperactivity disorder.Frontiers in psychology · 2023Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A repeated finding regarding event-related potentials (ERPs) is that patients with ADHD show a reduced P300 amplitude. This raises the question of whether the attention of ADHD patients can be increased by stabilizing the P300. Assuming that the P300 is generated by event-related oscillations (EROs) in the low frequency range (0-8 Hz), one approach to increase the P300 could be to stimulate the patient's P300 underlying ERO by means of transcranial alternating current stimulation (tACS). The aim of this follow-up study was to investigate this hypothesized mechanism of action in adult ADHD patients. Materials and Methods: Undergoing a crossover design, 20 adult ADHD patients (10 female) received an actual stimulation Results: Electrophysiological analyses revealed no evidence for an enhanced P300 amplitude or low frequency power increase after actual stimulation compared to sham stimulation. Instead, a significant effect was found for a stronger N700 amplitude increase after actual stimulation compared to sham stimulation. Consistent with the P300 null results, none of the examined neuropsychological performance measures indicated a tACS-induced improvement in attentional ability. Conclusion: Contrary to a previous study using tACS to modulate the P300 in adult ADHD patients, the current study yields no evidence that tACS can increase the P300 amplitude in adult ADHD patients and that such P300 enhancement can directly improve neuropsychological parameters of attention.
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Registered trials
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