Evidence map›Paper›PMID 35923349›Full record

ArticleNeurology. Genetics2022

Questioning the Association of the

Jay P Ross, Fulya Akçimen, Calwing Liao, Dan Spiegelman, Ben Weisburd, Nicolas Dupré, Patrick A Dion, Guy A Rouleau, Sali M K Farhan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jay P RossDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.ORCID https://orcid.org/0000-0002-8183-2524
Fulya AkçimenDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.ORCID https://orcid.org/0000-0003-0931-5247
Calwing LiaoDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.ORCID https://orcid.org/0000-0001-6169-7137
Dan SpiegelmanDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.
Ben WeisburdDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.ORCID https://orcid.org/0000-0001-9898-9109
Nicolas DupréDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.
Patrick A DionDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.
Guy A RouleauDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.
Sali M K FarhanDepartment of Human Genetics (J.P.R., F.A., C.L., G.A.R., S.M.K.F.), Montreal Neurological Institute and Hospital (J.P.R., F.A., C.L., D.S., P.A.D., G.A.R., S.M.K.F.), and Department of Neurology and Neurosurgery (D.S., P.A.D., G.A.R., S.M.K.F.), McGill University, Montréal, Quebec, Canada; Program in Medical and Population Genetics (B.W.), The Broad Institute of MIT and Harvard, Cambridge, MA; Division of Neurosciences (N.D.), CHU de Québec, Université Laval; and Department of Medicine (N.D.), Faculty of Medicine, Université Laval, Québec City, Canada.
Montreal Neurological Institute and Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Recently, the number of dinucleotide CA repeats in an intron of the Methods: Here, we used whole-genome sequencing and tested the Results: We find that repeats well above the previously reported pathogenic threshold of 19 are commonly observed in unaffected individuals across different populations. Furthermore, we did not observe an association between longer Discussion: In summary, our results do not support a role of

Identifiers

PMID35923349
PMCPMC9342143
OpenAlexW4285394094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.