ArticleFrontiers in nutrition2022
Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Article
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- The impact of the endocrine-disrupting chemicals on the glucose-6-phosphate dehydrogenase enzyme activity.Frontiers in pharmacology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Genistein is a dietary supplement with phyto-estrogenic properties. Therefore, high intake of genistein during pregnancy may have adverse effects on the genetic integrity of testes and germ cells of male offspring. In this study, we examined whether maternal exposure to genistein during pregnancy induced oxidative DNA damage in the male germline at adolescence. Methods: Results: Intake of genistein during pregnancy increased oxidative DNA damage in testes of offspring, especially in heterozygous Conclusion: These data indicate that prenatal exposure to genistein altered gene expression and increased DNA damage in testes and sperm of adolescent male offspring. These effects of genistein on DNA damage in later life coincided with alterations in DNA methylation.
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