ArticlePlant communications2022
Integrated network analyses identify MYB4R1 neofunctionalization in the UV-B adaptation of Tartary buckwheat.
Article in Plant communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Physiological and multi-omics insights into ultraviolet B-induced stress adaptation in Fritillaria cirrhosa native to the Qinghai-Tibet Plateau.Journal of advanced research · 2026Article
- Regulatory mechanisms of amino acid metabolic pathways in Rhododendron chrysanthum Pall. Under UV-B stress.PloS one · 2026Article
- Learning from nature: phytochemical strategies to protect against UV-B damage.Nature communications · 2025Review
- Leveraging genetic resources and genomic prediction to enhance flavonol content in cranberry fruit.The plant genome · 2025Article
- Genomic Analysis ofJournal of fungi (Basel, Switzerland) · 2025Article
- Transgenerational genetic and epigenetic changes induced by gamma-ray in Fagopyrum species.BMC plant biology · 2025Article
- Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell-Type Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular underpinnings ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Harnessing Light Quality for Potato Production: Red and Blue Light as Key Regulators of Growth and Yield.Plants (Basel, Switzerland) · 2025Article
- Optimization of Ultraviolet-B Treatment for Enrichment of Total Flavonoids in Buckwheat Sprouts Using Response Surface Methodology and Study on Its Metabolic Mechanism.Foods (Basel, Switzerland) · 2024Article
- Metabolomic Analysis ofMolecules (Basel, Switzerland) · 2024Article
- DNA methylation analysis of floral parts revealed dynamic changes during the development of homostylous Fagopyrum tataricum and heterostylous F. esculentum flowers.BMC plant biology · 2024Article
- Genome-wide investigation of UDP-Glycosyltransferase family in Tartary buckwheat (Fagopyrum tataricum).BMC plant biology · 2024Article
- Genome-Wide Association Studies on the Kernel Row Number in a Multi-Parent Maize Population.International journal of molecular sciences · 2024Article
- UV-B promotes flavonoid biosynthesis inHorticulture research · 2023Article
- Light-Induced Flavonoid Biosynthesis inPlants (Basel, Switzerland) · 2023Article
- Phenotyping ofPlant phenomics (Washington, D.C.) · 2023Article
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8 authors.
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Abstract
A hallmark of adaptive evolution is innovation in gene function, which is associated with the development of distinct roles for genes during plant evolution; however, assessing functional innovation over long periods of time is not trivial. Tartary buckwheat (Fagopyrum tataricum) originated in the Himalayan region and has been exposed to intense UV-B radiation for a long time, making it an ideal species for studying novel UV-B response mechanisms in plants. Here, we developed a workflow to obtain a co-functional network of UV-B responses using data from more than 10,000 samples in more than 80 projects with multi-species and multi-omics data. Dissecting the entire network revealed that flavonoid biosynthesis was most significantly related to the UV-B response. Importantly, we found that the regulatory factor MYB4R1, which resides at the core of the network, has undergone neofunctionalization. In vitro and in vivo experiments demonstrated that MYB4R1 regulates flavonoid and anthocyanin accumulation in response to UV-B in buckwheat by binding to L-box motifs in the FtCHS, FtFLS, and FtUFGT promoters. We used deep learning to develop a visual discrimination model of buckwheat flavonoid content based on natural populations exposed to global UV-B radiation. Our study highlights the critical role of gene neofunctionalization in UV-B adaptation.
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