Evidence map›Paper›PMID 35922803›Full record

ArticleMalaria journal2022

The in-vivo dynamics of Plasmodium falciparum HRP2: implications for the use of rapid diagnostic tests in malaria elimination.

Louise Marquart, Lachlan Webb, Peter O'Rourke, Michelle L Gatton, Michelle S Hsiang, Michael Kalnoky, Ihn Kyung Jang, Henry Ntuku, Davis R Mumbengegwi, Gonzalo J Domingo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Louise MarquartQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. l.marquart@uq.edu.au.ORCID http://orcid.org/0000-0003-4607-9060
Lachlan WebbQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Peter O'RourkeQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Michelle L GattonQueensland University of Technology, Brisbane, QLD, Australia.
Michelle S HsiangDepartment of Pediatrics, University of Texas, Southwestern, Dallas, TX, USA.
Michael KalnokyDiagnostics Program, PATH, Seattle, WA, USA.
Ihn Kyung JangDiagnostics Program, PATH, Seattle, WA, USA.
Henry NtukuMalaria Elimination Initiative, Institute for Global Health Services, University of California, San Francisco, CA, USA.
Davis R MumbengegwiMultidisciplinary Research Centre, University of Namibia, Windhoek, Namibia.
Gonzalo J DomingoDiagnostics Program, PATH, Seattle, WA, USA.
James S McCarthy *QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Sumudu Britton *QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Program for Appropriate Technology in Health · USThe University of Queensland · AUQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AUUniversity of California, San Francisco · USUniversity of Namibia · NA

Funding

Bill and Melinda Gates Foundation A128488Bill and Melinda Gates Foundation OPP1135840Global Health Innovation and Technology Fund (GHIT) G2014-108National Health and Medical Research Council APP1135955National Health and Medical Research Council Program Grant 1132975University of Texas Southwestern Department of Pediatrics Horchow Family Fund 5300375400Wellcome TrustWellcome Trust 095909/Z/11/Z
6 · The paper itself

Abstract

backgroundRapid diagnostic tests (RDTs) that rely on the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) have become key tools for diagnosing P. falciparum infection. The utility of RDTs can be limited by PfHRP2 persistence, however it can be a potential benefit in low transmission settings where detection of persistent PfHRP2 using newer ultra-sensitive PfHRP2 based RDTs can serve as a surveillance tool to identify recent exposure. Better understanding of the dynamics of PfHRP2 over the course of a malaria infection can inform optimal use of RDTs.

methodsA previously published mathematical model was refined to mimic the production and decay of PfHRP2 during a malaria infection. Data from 15 individuals from volunteer infection studies were used to update the original model and estimate key model parameters. The refined model was applied to a cohort of patients from Namibia who received treatment for clinical malaria infection for whom longitudinal PfHRP2 concentrations were measured.

resultsThe refinement of the PfHRP2 dynamic model indicated that in malaria naïve hosts, P. falciparum parasites of the 3D7 strain produce 33.6 × 10

conclusionsThe updated mathematical model can predict the growth and clearance of PfHRP2 during the production and decay of a mono-infection with P. falciparum, increasing the understanding of PfHRP2 antigen dynamics. This model can guide the optimal use of PfHRP2-based RDTs for reliable diagnosis of P. falciparum infection and re-infection in endemic settings, but also for malaria surveillance and elimination programmes in low transmission areas.

Indexed as

Malaria, FalciparumPlasmodium falciparumAdultAntigens, ProtozoanDiagnostic Tests, RoutineHumansModels, TheoreticalNamibiaProtozoan ProteinsAntigens, ProtozoanProtozoan ProteinsAntigen dynamicsElimination and surveillanceHistidine rich proteinPlasmodium falciparumRapid diagnostic tests

Identifiers

PMID35922803
PMCPMC9351188
OpenAlexW4289550330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.