Evidence map›Paper›PMID 35922692›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2022

Immunopotential of Pasteurella multocida bivalent outer membrane protein-based vaccine entrapped in aluminum hydroxide nanoparticles.

Haladhar Pegu, Shantanu Tamuly, Rajeev Kumar Sharma, Probodh Borah, Rita Nath

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haladhar PeguDepartment of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 781022, India.ORCID http://orcid.org/0000-0002-7818-4589
Shantanu TamulyDepartment of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 781022, India. drsan100@gmail.com.ORCID http://orcid.org/0000-0002-3767-3255
Rajeev Kumar SharmaDepartment of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 781022, India.ORCID http://orcid.org/0000-0003-4212-5082
Probodh BorahDepartment of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 781022, India.ORCID http://orcid.org/0000-0002-3010-1246
Rita NathDepartment of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 781022, India.
Assam Agricultural University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swine pasteurellosis is one of the most economically important diseases of pig caused by Pasteurella multocida (P. multocida) capsular types A and D. These organisms are commensals and opportunistic pathogens in the upper respiratory tract in pig. In the present study, we extracted whole outer membrane proteins (OMP) from P. multocida capsular types A and D and were mixed together in the ratio of 1:1 forming bivalent outer-membrane proteins. The bivalent OMP was adsorbed onto aluminum hydroxide nanoparticles. The size of aluminum hydroxide nanoparticles adsorbed outer membrane protein was found to be in the range of 125 to 130 nm. We observed that aluminum hydroxide nanoparticles adjuvanted bivalent OMP-based vaccine elicited quicker immune kinetics in terms of IgG response as compared to aluminum hydroxide microparticles adjuvanted bivalent bacterin vaccine against P. multocida capsular type A and D.

Indexed as

NanoparticlesPasteurella InfectionsPasteurella multocidaAluminum HydroxideAnimalsBacterial Outer Membrane ProteinsSwineVaccines, CombinedAluminum HydroxideBacterial Outer Membrane ProteinsVaccines, CombinedAluminum hydroxideNanoparticlesOuter membrane protein (OMP)Pasteurella multocidaVaccine

Identifiers

PMID35922692
PMCPMC9679094
OpenAlexW4289654147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.