Evidence map›Paper›PMID 35922657›Full record

ArticleScientific reports2022

Performance and usability testing of an automated tool for detection of peripheral artery disease using electronic health records.

I Ghanzouri, S Amal, V Ho, L Safarnejad, J Cabot, C G Brown-Johnson, N Leeper, S Asch, N H Shah, E G Ross

Registry-linked trialAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06505317 (Artificial Intelligence for Early Detection of Peripheral Artery Disease), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06505317 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Artificial Intelligence for Early Detection of Peripheral Artery Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2028Enrolled7,800ConditionsPeripheral Arterial DiseaseArmsAI-based PAD screening intervention
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. End Users' Perceived Engagement with Clinical Dashboards: A Rapid Review.Studies in health technology and informatics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

I Ghanzouri *Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
S Amal *Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
V Ho *Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
L SafarnejadDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
J CabotDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
C G Brown-JohnsonDepartment of Medicine, Primary Care and Population Health, Stanford, CA, USA.
N LeeperDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
S AschDepartment of Medicine, Primary Care and Population Health, Stanford, CA, USA.
N H ShahDepartment of Medicine, Center for Biomedical Informatics Research, Stanford University School of Medicine, 780 Welch Road, CJ350, Stanford, CA, 94305, USA.
E G RossDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA. elsie.ross@stanford.edu.

Funding

Clonal expansion, resistance to efferocytosis and innate immunity in atherosclerosisR35HL144475 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2019 to 2024
$5.1M
Methods for generalized ontology terms enrichment analysisR01LM011369 · NLM · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2013 to 2020
$5.0M
Using Artificial Intelligence to Enable Early Identification and Treatment of Peripheral Artery DiseaseK01HL148639 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSS, ELSIE GYANG · 2019 to 2023
$807k
NHLBI NIH HHS K01 HL148639NHLBI NIH HHS K01HL148639-03NHLBI NIH HHS R35 HL144475NHLBI NIH HHS R35HL144475NLM NIH HHS R01 LM011369NLM NIH HHS R01LM011369-08
6 · The paper itself

Abstract

Peripheral artery disease (PAD) is a common cardiovascular disorder that is frequently underdiagnosed, which can lead to poorer outcomes due to lower rates of medical optimization. We aimed to develop an automated tool to identify undiagnosed PAD and evaluate physician acceptance of a dashboard representation of risk assessment. Data were derived from electronic health records (EHR). We developed and compared traditional risk score models to novel machine learning models. For usability testing, primary and specialty care physicians were recruited and interviewed until thematic saturation. Data from 3168 patients with PAD and 16,863 controls were utilized. Results showed a deep learning model that utilized time engineered features outperformed random forest and traditional logistic regression models (average AUCs 0.96, 0.91 and 0.81, respectively), P < 0.0001. Of interviewed physicians, 75% were receptive to an EHR-based automated PAD model. Feedback emphasized workflow optimization, including integrating risk assessments directly into the EHR, using dashboard designs that minimize clicks, and providing risk assessments for clinically complex patients. In conclusion, we demonstrate that EHR-based machine learning models can accurately detect risk of PAD and that physicians are receptive to automated risk detection for PAD. Future research aims to prospectively validate model performance and impact on patient outcomes.

Indexed as

Electronic Health RecordsPeripheral Arterial DiseaseHumansMachine LearningUser-Centered DesignUser-Computer Interface

Identifiers

PMID35922657
PMCPMC9349186

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.