SynthesisScientific reports2022
The relationship between tooth loss and hypertension: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Examining the link between tooth loss and multiple health outcomes: a comprehensive synthesis of evidence from meta-analyses.Frontiers in public health · 2026Pooled it
- Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population.BMC musculoskeletal disorders · 2024Pooled it
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Salivary glutathione peroxidase-1 levels in periodontitis.World journal of methodology · 2026Article
- Association Between Arterial Hypertension and Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Oral Health and Cardiovascular Disease Among Hypertensive Medicated Adults With Uncontrolled Blood Pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Integrated transcriptomic and metabolomic analysis to elucidate key genes and signaling pathways involved in the promotion of periodontitis by hypertension.Scientific reports · 2026Article
- Can the Severity of Dental Caries Predict Hypertension in Adult Patients?Health science reports · 2026Article
- Low salivary thioredoxin-1 levels in periodontitis.World journal of clinical cases · 2026Article
- Association Between Salivary Sirtuin-1 Levels and Periodontitis.Journal of clinical medicine · 2026Article
- Development of an Oral Health Index and Its Association with Oral Health-Related Quality of Life and Cardiovascular Risks: A Cross-Sectional Study.International journal of environmental research and public health · 2026Observational
- High Salivary 3-Nitrotyrosine Levels in Periodontitis.Journal of clinical medicine · 2025Article
- Low salivary uric acid levels are independently associated with periodontitis.World journal of clinical cases · 2025Article
- High Salivary Malondialdehyde Levels Are Associated with Periodontitis Independently of Other Risk Factors.Journal of clinical medicine · 2025Article
- Lifestyles associated with complete tooth loss in elderly people in Brazil, 2019.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- The effectiveness of a self-reported questionnaire on masticatory function in health examinations.Odontology · 2024Article
- Tooth Loss and Systemic Diseases in the Slovenian Elderly Population: A Cross-Sectional Study of the Associaton Between Oral and Systemic Health.Zdravstveno varstvo · 2024Article
- Oral health as a modifiable risk factor for cardiovascular diseases.Trends in cardiovascular medicine · 2024Review
- Crosstalk between periodontitis and cardiovascular risk.Frontiers in immunology · 2024Review
- Risk Factors for Delayed-Onset Infection after Mandibular Wisdom Tooth Extractions.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As tooth loss is the high end of periodontal problems and edentulous individuals are at higher risk of nutritional problems like obesity, understanding the association between tooth loss and hypertension is important for improving cardiovascular health. We searched for publications from the last two decades using three electronic databases (PubMed, Web of Science and Scopus) and conducted a systematic review and meta-analysis on the association between tooth loss and hypertension according to PRISMA-P guidelines. Quality assessments were performed using the Newcastle-Ottawa Scale and the GRADE approach. Twenty-four studies (20 cross-sectional, and 4 cohort) met the inclusion criteria for this review. Most cross-sectional studies showed that subjects with more tooth loss exhibited a greater proportion of hypertension and higher systolic blood pressure than those with less tooth loss. Meta-analyses revealed a statistically significant association between tooth loss and hypertension. The pooled odds ratios of hypertension for having tooth loss with no tooth loss and for edentulous with dentate were 2.22 (95% CI 2.00-2.45) and 4.94 (95% CI 4.04-6.05), respectively. In cohort studies, subjects with more tooth loss had a greater incidence of hypertension than those with less tooth loss during the follow-up period. The present systematic review and meta-analysis suggests that tooth loss is associated with an increased risk of hypertension and higher systolic blood pressure.
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