Evidence map›Paper›PMID 35922518›Full record

ArticleScientific reports2022

Histopathological evaluation of a retinoic acid eluting stent in a rabbit iliac artery model.

Ioanna Samara, Christos S Katsouras, Arsen Semertzioglou, Athanassios Vratimos, Amalia I Moula, Constantinos A Dimitriou, Michail Theofanis, Triantafyllia Papadimitropoulou, Vasileios Bouratzis, Georgia Karanasiou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Ioanna Samara *2nd Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece.
Christos S Katsouras *2nd Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece.
Arsen SemertzioglouRontis Corporation, Zug, Switzerland.
Athanassios VratimosRontis Corporation, Zug, Switzerland.
Amalia I MoulaGeneral Department, University of Thessaly, Larissa, Greece.
Constantinos A DimitriouCenter for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Michail TheofanisDepartment of Interventional Radiology, University Hospital of Patras, Patras, Greece.
Triantafyllia PapadimitropoulouGeneral Department, University of Thessaly, Larissa, Greece.
Vasileios BouratzisFaculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Georgia KaranasiouDepartment of Biomedical Research, Institute of Molecular Biology and Biotechnology, University of Ioannina, Ioannina, Greece.
Dimitrios FotiadisDepartment of Biomedical Research, Institute of Molecular Biology and Biotechnology, University of Ioannina, Ioannina, Greece.
Lampros K Michalis2nd Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece.
Anargyros N MoulasGeneral Department, University of Thessaly, Larissa, Greece. moulas@uth.gr.
University of Ioannina · GRUniversity Hospital of Ioannina · GRUniversity of Thessaly · GRBiomedical Research Foundation of the Academy of Athens · GRGeneral University Hospital of Patras · GRMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the safety and efficacy of innovative retinoic acid (RA) eluting stents with bioabsorbable polymer. Sixty stents divided in ten groups were implanted in the iliac arteries of 30 rabbits. Two polymers ("A", poly (lactic-co-glycolic acid) and "B", polylactic acid), and three doses ("Low", "Medium" and "High") of RA (groups: AL, AM, AH, BL, BM, BH) were used on cobalt chromium stents (Rontis Corporation), one group of bare stent (C), one group (D) of Everolimus eluting stent (Xience-Pro, Abbot Vascular), and two groups of Rontis Everolimus eluting stents coated with polymer A (EA) and B (EB). Treated arteries were explanted after 4 weeks, processed by methyl methacrylate resin and evaluated by histopathology. None of the implanted stents was related with thrombus formation or extensive inflammation. Image analysis showed limited differences between groups regarding area stenosis (BH, D and EB groups had the lower values). Group BH had lower intimal mean thickness than AH (105.1 vs 75.3 μm, p = 0.024). Stents eluting RA, a non-cytotoxic drug, were not related with thrombus formation and had an acceptable degree of stenosis 4 weeks post implantation. RA dose and type of polymer may play role in the biocompatibility of the stents.

Indexed as

Drug-Eluting StentsIliac ArteryAnimalsConstriction, PathologicEverolimusPolymersRabbitsStentsTretinoinEverolimusPolymersTretinoin

Identifiers

PMID35922518
PMCPMC9349184
OpenAlexW4289544983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.