ArticleNature2022
RNA editing underlies genetic risk of common inflammatory diseases.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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130citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
130 citing papers in PubMed, 191 citations in OpenAlex.
- dsRNAscan maps human dsRNAome, revealing conservation, intermolecular dsRNA, and correlates of ADAR dependency.Molecular cell · 2026Article
- EndoV does not measurably affect TadA-dependent A-to-I RNA editing inMicrobiology spectrum · 2026Article
- Atlas of glomerular disease-specific genetic effects on blood transcriptome.medRxiv : the preprint server for health sciences · 2026Article
- RModBlock antisense oligonucleotides as a universal tool for precise and efficient inhibition of RNA modifications.Nature biomedical engineering · 2026Article
- A cytoplasmic index for quantifying immune-related A-to-I RNA editing.Genome biology · 2026Article
- Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments.bioRxiv : the preprint server for biology · 2026Article
- Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- A mitochondrial ROS-dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes.Science translational medicine · 2026Article
- Article
- A transcriptome-wide systematic search does not detect A-to-I RNA editing inGenome research · 2026Article
- Inducible, split base editors for in vivo cancer functional genomics.Nature biotechnology · 2026Article
- Adenosine-to-Inosine (A-to-I) RNA Editing by ADAR1 to Control RNA Sensing in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation.Cell insight · 2026Review
- TYK2 mediates neuroinflammation in Alzheimer's disease brains with TDP-43 pathology.Nature communications · 2026Article
- Knockdown of RNA editing proteins reshapes the HepaRG transcriptome and pharmacogene expression.Scientific reports · 2026Article
- ADAR-GPT: Learning the language of the epitranscriptome.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrated heart-blood RNA editome profiling reveals circulating A-to-I editing candidates linked to dilated cardiomyopathy myocardial signatures and heart failure.Journal of molecular and cellular cardiology plus · 2026Article
- Multi-Tissue Genetic Regulation of RNA Editing in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- Two codes of RNA editing by deamination in human diseases.Experimental & molecular medicine · 2026Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Qin LiDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8948-2717
Michael J GloudemansDepartment of Pathology, Stanford University, Stanford, CA, USA.
Jonathan M GeisingerDepartment of Genetics, Stanford University, Stanford, CA, USA.
Boming FanState Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai, China.
François AguetBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9414-300X
Tao SunDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2800-0921
Gokul RamaswamiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Yang I LiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Jin-Biao MaState Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai, China.
Jonathan K PritchardDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8828-5236
Stephen B Montgomery *Department of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5200-3903
Jin Billy Li *Department of Genetics, Stanford University, Stanford, CA, USA. jin.billy.li@stanford.edu.ORCID http://orcid.org/0000-0003-0713-1399
Stanford University · USFudan University · CNBroad Institute · USUniversity of Chicago · US
Funding
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5MIntegration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3MMapping Molecular and Phenotypic Interactions in Alzheimers DiseaseR01AG066490 · NIA · STANFORD UNIVERSITY · PI MONTGOMERY, STEPHEN · 2020 to 2024
$3.6MDecoding the regulatory architecture of the human genome across cell types, individuals and diseaseU01HG009431 · NHGRI · STANFORD UNIVERSITY · PI PRITCHARD, JONATHAN K · 2017 to 2021
$3.5MRegulatory and Mechanistic Understanding of ADAR-Mediated RNA EditingR35GM144100 · NIGMS · STANFORD UNIVERSITY · PI Jin Billy Li · 2022 to 2026
$3.2MProfiling and Dissecting the Dynamic Regulation of RNA EditingR01GM102484 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2013 to 2021
$3.1MIdentifying causal genetic variants and molecular mechanisms impacting mental healthR01MH125244 · NIMH · STANFORD UNIVERSITY · PI KUNDAJE, ANSHUL, MONTGOMERY, STEPHEN · 2021 to 2025
$3.0MSystematic characterization of trans regulation of A-to-I RNA editing in neuronsR01MH115080 · NIMH · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2021
$2.3MSystematic identification and characterization of immunogenic double-stranded RNAsR01AI182437 · NIAID · STANFORD UNIVERSITY · PI Jin Billy Li · 2024 to 2026
$2.1MSystematic approaches to deciphering cis regulation of A-to-I RNA editingR01GM124215 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2020
$1.7MHIGH RESOLUTION ALLELE SPECIFIC EXPRESSION ASSAYSU01HG007593 · NHGRI · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2014 to 2016
$1.3MAmerican Heart Association-American Stroke Association 17IFUNP33820059NHGRI NIH HHS R01 HG008140NHGRI NIH HHS U01 HG007593NHGRI NIH HHS U01 HG009431NIAID NIH HHS R01 AI182437NIA NIH HHS R01 AG066490NIGMS NIH HHS R01 GM102484NIGMS NIH HHS R01 GM124215NIGMS NIH HHS R35 GM144100NIMH NIH HHS R01 MH115080NIMH NIH HHS R01 MH125244
Abstract
A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes such as gene expression and splicing have been widely adopted
Indexed as
Adenosine DeaminaseGenetic Predisposition to DiseaseImmune System DiseasesInflammationRNA, Double-StrandedRNA EditingAdenosineAlu ElementsAutoimmune DiseasesGenome-Wide Association StudyHumansImmunity, InnateInosineInterferon-Induced Helicase, IFIH1InterferonsQuantitative Trait LociADAR protein, humanAdenosineAdenosine DeaminaseIFIH1 protein, humanInosineInterferon-Induced Helicase, IFIH1InterferonsRNA-Binding ProteinsRNA, Double-Stranded
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.