ArticleNature2022
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
25.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 184 citations in OpenAlex.
- Natural molecule potentiates colistin efficacyVirulence · 2026Article
- The efflux pump QacA mediates the transition to vancomycin heteroresistance in sequence type 5 methicillin-resistantEmerging microbes & infections · 2026Article
- Antibiotic-producing microorganisms: taxonomic diversity, screening strategies, and emerging and underexploited antibacterial targets.Archives of microbiology · 2026Review
- Understanding the Role of Macrocycle Size and Amide Linkage in Teixobactin Analogues.Biomolecules · 2026Article
- Molecular action of NZ2114, a superior plectasin derivative.npj antimicrobials and resistance · 2026Article
- Article
- Design and Development of Teixobactin Analog-Loaded Magnetic Nanocomposites for Biofilm Destruction and Pathogen Elimination.Journal of functional biomaterials · 2026Article
- SET-M33 peptide as a selectiveMicrobiology spectrum · 2026Article
- Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026Review
- Pardon the interruption: how Und-P sequestration has reshaped our understanding of the bacterial cell envelope.Journal of bacteriology · 2026Review
- Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026Review
- Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides.Frontiers in chemistry · 2026Review
- Case Study: Illuminating the Nanoscale World of Microbiology.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Defensins as natural antimicrobial peptide scaffolds against antimicrobial-resistant pathogens: mechanisms, resistance risks, and translational prospects.Frontiers in cellular and infection microbiology · 2026Review
- Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials inAntimicrobial agents and chemotherapy · 2025Article
- BroadAMP-GPT: AI-Driven generation of broad-spectrum antimicrobial peptides for combating multidrug-resistant ESKAPE pathogens.Gut microbes · 2025Article
- YZ462 exhibits potent antibacterial activity against methicillin-resistant Staphylococcus aureus through bacterial membrane disruption.BMC microbiology · 2025Article
- Mining Microbial Dark Matter: Advanced Cultivation Techniques for Bioactive Compound Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The interaction of small molecules with phospholipid membranes studied by solid-state NMR and molecular dynamics simulation.Biophysical reviews · 2025Review
- Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation.Journal of medicinal chemistry · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 3 countries.
Rhythm ShuklaNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-1792-6582
Francesca LavoreNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Sourav MaityMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.
Maik G N DerksNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-8962-5362
Chelsea R JonesDepartment of Chemistry, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8347-6885
Bram J A VermeulenNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-9798-6245
Adéla MelcrováMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-6390-0522
Michael A MorrisDepartment of Chemistry, University of California Irvine, Irvine, CA, USA.
Lea Marie BeckerNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-6401-5151
Xiaoqi WangMembrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-4478-9245
Raj KumarNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
João Medeiros-SilvaNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3532-4390
Roy A M van BeekveldNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-8897-1669
Alexandre M J J BonvinNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-7369-1322
Joseph H LorentMembrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7537-8521
Moreno LelliMagnetic Resonance Center (CERM) and Department of Chemistry 'Ugo Schiff', University of Florence, Sesto Fiorentino (FI), Italy.
James S NowickDepartment of Chemistry, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-2273-1029
Harold D MacGillavryCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-6153-3586
Aaron J PeoplesNovoBiotic Pharmaceuticals, Cambridge, MA, USA.
Amy L SpoeringNovoBiotic Pharmaceuticals, Cambridge, MA, USA.
Losee L LingNovoBiotic Pharmaceuticals, Cambridge, MA, USA.
Dallas E HughesNovoBiotic Pharmaceuticals, Cambridge, MA, USA.
Wouter H RoosMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-5104-0139
Eefjan BreukinkMembrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7311-0660
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Markus WeingarthNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands. m.h.weingarth@uu.nl.ORCID http://orcid.org/0000-0003-0831-8673
Utrecht University · NLNovoBiotic Pharmaceuticals · USUniversity of California, Irvine · USUniversity of Groningen · NLInteruniversity Consortium for Magnetic Resonance · ITNortheastern University · USUniversity of Applied Sciences Utrecht · NL
Funding
European Research Council
Abstract
Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance
Indexed as
Anti-Bacterial AgentsBacteriaCell MembraneDepsipeptidesMicrobial ViabilityAlanineCell WallDiphosphatesDrug Resistance, BacterialHumansLipidsMicrobial Sensitivity TestsMicroscopy, Atomic ForceMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein Structure, SecondaryAlanineAnti-Bacterial AgentsDepsipeptidesDiphosphatesL-allo-enduracididineLipidsPyrrolidinesSugarsteixobactin
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.