ArticleNature2022
Brown-fat-mediated tumour suppression by cold-altered global metabolism.
2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 148 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 1 pooled it
29.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Milaberon in Combination With Standard Therapy in Advanced Solid Tumors: an Open, Multicenter, Clinical Study
NIVALIS Trial: A Single-Center, Prospective, Single-Arm, Open-Label Phase I Exploratory Study Evaluating the Safety, Feasibility, and Preliminary Antitumor Activity of Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Patients With Solid Tumors
Who cites it
148 citing papers in PubMed, 1 synthesis or guideline pooled it, 265 citations in OpenAlex.
- [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.Genes & diseases · 2027Review
- Review
- Article
- Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.Cell research · 2026Article
- TRPA1 deficiency alters brown adipose tissue proteome and thermogenic gene expression during cold exposure in mice.Biochemistry and biophysics reports · 2026Article
- Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression.Signal transduction and targeted therapy · 2026Review
- Cardio-Oncology in Cold Climates: Epidemiological Features, Bidirectional Interaction Mechanisms, and Integrated Management Strategies.Cardiovascular toxicology · 2026Review
- Adipose Tissue Heterogeneity: Depot-Specific Location and Functional Specialization in Obesity-Related Disease.International journal of molecular sciences · 2026Review
- Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.Cell biochemistry and function · 2026Review
- Adipocytes in cancer a metabolic paradox and the dawn of novel therapeutics.Discover oncology · 2026Review
- Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway.Journal of nanobiotechnology · 2026Article
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- Transient Plasmonic Photothermal Imaging Deciphers Dynamic Thermal Transfer during the Cell Cycle.Chemical & biomedical imaging · 2026Article
- Brown Adipocyte Promotes HR+ Breast Cancer Invasiveness Through IRX3-Mediated Mitochondrial Dysfunction.Metabolites · 2026Article
- Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond.Physiological reports · 2026Review
- CDH4/UBA1/RBMX axis promotes polycystic ovary syndrome progression through YAP1 activation.Cellular & molecular biology letters · 2026Article
- Decoding Adipose Tissue Phenotypic Switching: From Mechanisms to Computational Drug Discovery.Current obesity reports · 2026Review
- Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue.Current obesity reports · 2026Review
- Cold Exposure Alleviates Colitis via Parallel Integration of Colonic Mucosal Regeneration and Ileal Antimicrobial Defense.Biomedicines · 2026Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Takahiro Seki *Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0001-8910-4612
Yunlong Yang *Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-1551-9828
Xiaoting SunDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-0622-8092
Sharon LimDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-9681-4935
Sisi XieDepartment of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Ziheng GuoDepartment of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-2879-0214
Wenjing XiongDepartment Nuclear Medicine, Department of Emergency Medicine, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.ORCID http://orcid.org/0000-0002-9213-3278
Masashi KurodaDepartment of Nutrition and Metabolism, Tokushima University Graduate School, Tokushima, Japan.ORCID http://orcid.org/0000-0001-9226-0579
Hiroshi SakaueDepartment of Nutrition and Metabolism, Tokushima University Graduate School, Tokushima, Japan.ORCID http://orcid.org/0000-0002-2468-2363
Kayoko HosakaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0001-9488-8669
Xu JingDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-4864-1870
Masahito YoshiharaDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-8915-9282
Lili QuDepartment Nuclear Medicine, Department of Emergency Medicine, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-5661-013X
Xin LiDepartment Nuclear Medicine, Department of Emergency Medicine, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-9534-4911
Yuguo ChenDepartment Nuclear Medicine, Department of Emergency Medicine, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-9501-2546
Yihai CaoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden. yihai.cao@ki.se.ORCID http://orcid.org/0000-0003-1308-0065
Karolinska Institutet · SEQilu Hospital of Shandong University · CNTokushima University · JPFudan University · CNFujian Medical University · CNSichuan University · CNWenzhou Medical University · CN
Funding
European Research Council 250021
Abstract
Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues
Indexed as
Adipose Tissue, BrownCold TemperatureEnergy MetabolismNeoplasmsAdipocytesAnimalsBlood GlucoseCombined Modality TherapyGlycolysisHumansMicePancreatic NeoplasmsThermogenesisUncoupling Protein 1Blood GlucoseUcp1 protein, mouseUncoupling Protein 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06534762ClinicalTrials.gov
NCT07538479ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.