Evidence map›Paper›PMID 35922507›Full record

ArticleNature2022

A mitotic chromatin phase transition prevents perforation by microtubules.

Maximilian W G Schneider, Bryan A Gibson, Shotaro Otsuka, Maximilian F D Spicer, Mina Petrovic, Claudia Blaukopf, Christoph C H Langer, Paul Batty, Thejaswi Nagaraju, Lynda K Doolittle and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 111 citations in OpenAlex.

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  15. Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts.Genes to cells : devoted to molecular & cellular mechanisms · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Maximilian W G SchneiderInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria. maximilian.schneider@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0001-7485-0460
Bryan A Gibson *Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, USA.
Shotaro Otsuka *Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, Vienna BioCenter, Vienna, Austria.ORCID http://orcid.org/0000-0003-3976-0843
Maximilian F D SpicerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.ORCID http://orcid.org/0000-0001-8286-124X
Mina PetrovicInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.
Claudia BlaukopfInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.
Christoph C H LangerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.ORCID http://orcid.org/0000-0001-8751-1564
Paul BattyInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.ORCID http://orcid.org/0000-0002-9807-5099
Thejaswi NagarajuInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.
Lynda K DoolittleDepartment of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, USA.
Michael K RosenDepartment of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, USA.ORCID http://orcid.org/0000-0002-0775-7917
Daniel W GerlichInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria. daniel.gerlich@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0003-1637-3365
Institute of Molecular Biotechnology · ATHoward Hughes Medical Institute · USMax Perutz Labs · AT

Funding

Regulation of Chromatin by Phase SeparationF32GM129925 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GIBSON, BRYAN A · 2018 to 2021
$144k
Austrian Science Fund FWF W 1238Austrian Science Fund FWF W 1261European Research Council 101019039Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM129925
6 · The paper itself

Abstract

Dividing eukaryotic cells package extremely long chromosomal DNA molecules into discrete bodies to enable microtubule-mediated transport of one genome copy to each of the newly forming daughter cells

Indexed as

ChromatinMicrotubulesMitosisAcetylationChromosome SegregationDNAHistonesPhase TransitionSpindle ApparatusChromatinDNAHistones

Identifiers

PMID35922507
PMCPMC9433320
OpenAlexW4289637706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.