ArticleNature2022
Cellular recovery after prolonged warm ischaemia of the whole body.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- How Long Is the Brain Perfusable After Global Ischemia? A Systematic Review.Brain sciences · 2026Review
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- Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents.Nature medicine · 2026Article
- Evolutionary diversity of cell-type-specific expression and stress response in Brassicaceae roots.Nature communications · 2026Article
- Evolutionary diversity of cell-type-specific expression and stress response in Brassicaceae roots.bioRxiv : the preprint server for biology · 2026Article
- Healing of ischemic injury in the retina.Science advances · 2026Article
- Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.Nature communications · 2026Article
- Emergency preservation and resuscitation in exsanguination cardiac arrest: science fiction to future reality?Trauma surgery & acute care open · 2026Review
- Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Therapeutic hypothermia for acute ischemic stroke: from preclinical studies to clinical trials.Science China. Life sciences · 2025Review
- Transport physics-informed reinforcement learning agents deployed in standalone infusion pumps for managing multidrug delivery in critical care.Bioengineering & translational medicine · 2025Article
- Ice Water Drowning Survival After 147-Minute Submersion and 7 °C Hypothermic Circulatory Arrest.JACC. Case reports · 2025Article
- Normothermic human kidney preservation drives iron accumulation and ferroptosis.Nature communications · 2025Article
- Article
- A neuroscientific model of near-death experiences.Nature reviews. Neurology · 2025Review
- Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia.European journal of medical research · 2025Review
- The Heart Team approach to cardiac arrest.European heart journal supplements : journal of the European Society of Cardiology · 2025Article
- A mobile system for whole eye perfusion supporting retinal function and surgery.Frontiers in bioengineering and biotechnology · 2025Article
- Phospholipid Nanoparticles: A Novel Colloid for Blood Volume Replacement, Reanimation, and Organ Protection in Hemorrhagic Shock.Biomedicines · 2024Article
- Next generation preservation solution using synthetic enzymes added to polyhemoglobin to protect warm ischemic human hepatocytes and cardiomyocytes.Scientific reports · 2024Article
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Authors and funding
27 authors at 4 institutions in 1 country.
David Andrijevic *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5703-3837
Zvonimir Vrselja *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Taras Lysyy *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Shupei Zhang *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Mario SkaricaDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2478-014X
Ana SpajicDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
David DellalDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Stephanie L ThornYale Translational Research Imaging Center, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Robert B DuckrowDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Shaojie MaDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8782-3047
Phan Q DuyDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4513-7348
Atagun U IsiktasDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5459-6810
Dan LiangDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Mingfeng LiDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7959-6008
Suel-Kee KimDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0240-9304
Stefano G DanieleDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Khadija BanuDepartment of Nephrology, Yale School of Medicine, New Haven, CT, USA.
Sudhir PerincheriDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Madhav C MenonDepartment of Nephrology, Yale School of Medicine, New Haven, CT, USA.
Anita HuttnerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Kevin N ShethDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2003-5473
Kevin T GobeskeDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Gregory T TietjenDepartment of Surgery, Yale School of Medicine New Haven, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7227-2887
Hitten P ZaveriDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7830-0052
Stephen R LathamInterdisciplinary Center for Bioethics, Yale University, New Haven, CT, USA.
Albert J SinusasDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0972-9589
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.ORCID http://orcid.org/0000-0003-0966-9619
Yale University · USYale New Haven Hospital · USImaging Center · USYale Cancer Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MYale Macaque Brain ResourceR01MH113257 · NIMH · YALE UNIVERSITY · PI Alvaro Duque · 2017 to 2026
$4.3MTechnology for functional study of cells and circuits in large postmortem brains ex vivoRF1MH117064 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2018 to 2019
$3.0MDichotomous roles of Shroom3 in Tubular cells and Podocytes in native and allograft kidneysR01DK122164 · NIDDK · YALE UNIVERSITY · PI Madhav C Menon · 2019 to 2026
$2.7MRole of AMP-kinase pathway in the regulation of Minimal change disease-to-FSGS transitionR01DK132274 · NIDDK · YALE UNIVERSITY · PI Madhav C Menon · 2023 to 2026
$2.1MRedefining the limits of tolerable warm ischemia in deceased donor kidneysR21DK128662 · NIDDK · YALE UNIVERSITY · PI TIETJEN, GREGORY T · 2021 to 2022
$461kRole of TRIM71 in neural stem cell biology and congenital hydrocephalusF30HD106694 · NICHD · YALE UNIVERSITY · PI PHAN, DUY · 2021 to 2022
$56kNCATS NIH HHS UL1 TR001863NICHD NIH HHS F30 HD106694NIDDK NIH HHS R01 DK122164NIDDK NIH HHS R01 DK132274NIDDK NIH HHS R21 DK128662NIGMS NIH HHS T32 GM136651NIMH NIH HHS R01 MH113257NIMH NIH HHS RF1 MH117064
Abstract
After cessation of blood flow or similar ischaemic exposures, deleterious molecular cascades commence in mammalian cells, eventually leading to their death
Indexed as
Cell SurvivalCytoprotectionPerfusionSwineWarm IschemiaAnimalsCell DeathGene Expression ProfilingIschemiaOrgan Specificity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.