Evidence map›Paper›PMID 35922450›Full record

ArticleScientific reports2022

Methods to capture proteomic and metabolomic signatures from cerebrospinal fluid and serum of healthy individuals.

Laura M Lilley, Steven Sanche, Shepard C Moore, Michelle R Salemi, Dung Vu, Srinivas Iyer, Nicolas W Hengartner, Harshini Mukundan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Recent Advances in Human Cerebrospinal Fluid Proteomics.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura M LilleyLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Steven SancheLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Shepard C MooreLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Michelle R SalemiGenome Center, Proteomics Core Facility, University of California, Davis, CA, 95616, USA.
Dung VuLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Srinivas IyerLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Nicolas W HengartnerLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Harshini MukundanLos Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. harshini@lanl.gov.

Funding

West Coast Metabolomics Center for Compound IdentificationU2CES030158 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2018 to 2021
$4.1M
Phinney - Orbitrap Fusion ETDS10OD021801 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2016 to 2016
$600k
QE-HF-X Mass SpectrometerS10OD026918 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2020 to 2020
$600k
NIEHS NIH HHS U2C ES030158NIH HHS NIH U2C ES030158NIH HHS S10 OD021801NIH HHS S10 OD026918
6 · The paper itself

Abstract

Discovery of reliable signatures for the empirical diagnosis of neurological diseases-both infectious and non-infectious-remains unrealized. One of the primary challenges encountered in such studies is the lack of a comprehensive database representative of a signature background that exists in healthy individuals, and against which an aberrant event can be assessed. For neurological insults and injuries, it is important to understand the normal profile in the neuronal (cerebrospinal fluid) and systemic fluids (e.g., blood). Here, we present the first comparative multi-omic human database of signatures derived from a population of 30 individuals (15 males, 15 females, 23-74 years) of serum and cerebrospinal fluid. In addition to empirical signatures, we also assigned common pathways between serum and CSF. Together, our findings provide a cohort against which aberrant signature profiles in individuals with neurological injuries/disease can be assessed-providing a pathway for comprehensive diagnostics and therapeutics discovery.

Indexed as

Nervous System DiseasesProteomicsCerebrospinal FluidCohort StudiesFemaleHumansMaleMetabolomicsNeurons

Identifiers

PMID35922450
PMCPMC9349260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.