Evidence map›Paper›PMID 35922410›Full record

ArticleNature communications2022

Explaining a series of models by propagating Shapley values.

Hugh Chen, Scott M Lundberg, Su-In Lee

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hugh ChenPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, USA.ORCID 0000-0003-0549-4524
Scott M LundbergMicrosoft Research, Redmond, WA, USA.
Su-In LeePaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, USA. suinlee@cs.washington.edu.ORCID 0000-0001-5833-5215

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Pathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6M
Discovery of Novel Proteomic Targets in Alzheimer's DiseaseU01AG046161 · NIA · EMORY UNIVERSITY · PI BENNETT, DAVID ALAN, GESCHWIND, DANIEL H · 2014 to 2018
$8.4M
Exploring the Role of the Brain Transcriptome in Cognitive DeclineR01AG036836 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DE JAGER, PHILIP L · 2011 to 2014
$2.9M
Interpretable Machine Learning to Identify Alzheimer's Disease Therapeutic TargetsR01AG061132 · NIA · UNIVERSITY OF WASHINGTON · PI LEE, SU-IN · 2019 to 2023
$2.9M
Opening the Black Box of Machine Learning ModelsR35GM128638 · NIGMS · UNIVERSITY OF WASHINGTON · PI LEE, SU-IN · 2018 to 2022
$1.9M
Cancer Research UKNIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG061132NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIGMS NIH HHS R35 GM128638
6 · The paper itself

Abstract

Local feature attribution methods are increasingly used to explain complex machine learning models. However, current methods are limited because they are extremely expensive to compute or are not capable of explaining a distributed series of models where each model is owned by a separate institution. The latter is particularly important because it often arises in finance where explanations are mandated. Here, we present Generalized DeepSHAP (G-DeepSHAP), a tractable method to propagate local feature attributions through complex series of models based on a connection to the Shapley value. We evaluate G-DeepSHAP across biological, health, and financial datasets to show that it provides equally salient explanations an order of magnitude faster than existing model-agnostic attribution techniques and demonstrate its use in an important distributed series of models setting.

Indexed as

Machine Learning

Identifiers

PMID35922410
PMCPMC9349278

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.