Evidence map›Paper›PMID 35921959›Full record

ReviewBrain stimulation

Evoked potentials generated by deep brain stimulation for Parkinson's disease.

Jahrane Dale, Stephen L Schmidt, Kyle Mitchell, Dennis A Turner, Warren M Grill

Open access · goldAbstract readReview
In one paragraph

Review in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jahrane DaleDepartments of Biomedical Engineering, Duke University, Durham, NC, USA.
Stephen L SchmidtDepartments of Biomedical Engineering, Duke University, Durham, NC, USA.
Kyle MitchellDepartments of Neurology, Duke University, Durham, NC, USA.
Dennis A TurnerDepartments of Neurobiology, Duke University, Durham, NC, USA; Departments of Neurosurgery, Duke University, Durham, NC, USA.
Warren M GrillDepartments of Biomedical Engineering, Duke University, Durham, NC, USA; Departments of Neurobiology, Duke University, Durham, NC, USA; Departments of Neurosurgery, Duke University, Durham, NC, USA. Electronic address: warren.grill@duke.edu.
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Temporal Patterns of Deep Brain StimulationR37NS040894 · NINDS · DUKE UNIVERSITY · PI GRILL, WARREN M. · 2015 to 2021
$4.2M
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson DiseaseUH3NS129898 · NINDS · DUKE UNIVERSITY · PI DENNIS Alan TURNER · 2023 to 2026
$3.7M
Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous PotentialsUH3NS103468 · NINDS · DUKE UNIVERSITY · PI TURNER, DENNIS ALAN · 2017 to 2021
$2.0M
NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449NINDS NIH HHS R37 NS040894NINDS NIH HHS UH3 NS103468NINDS NIH HHS UH3 NS129898
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe goal of this review is to describe the general features, mechanisms, technical recording factors, and clinical applications of brain evoked potentials (EPs) generated by deep brain stimulation (DBS) for Parkinson's disease (PD).

resultsEvoked potentials in response to DBS pulses occur on the timescale of milliseconds and are found both locally at the site of stimulation and remotely in the cortex. DBS evoked potentials arise from a complex integration of antidromic and orthodromic conduction pathway responses, and provide information valuable for understanding the mechanisms and circuits involved in symptom treatment. Furthermore, these signals may provide biomarkers for improving DBS outcomes and function. For example, evoked potentials may have utility as control signals for DBS programming or adaptive DBS. Despite their promise there are still critical gaps in our understanding of the mechanisms by which evoked potentials arise and how these signals may be measured and applied in the clinical setting. Technical challenges of recording a highly transient signal at sufficient resolution without the interference of stimulation artifact present a barrier to understanding better DBS-induced EPs.

conclusionsWe describe the current scientific landscape of evoked potentials to facilitate and stimulate further investigation.

Indexed as

Deep Brain StimulationParkinson DiseaseArtifactsCerebral CortexEvoked PotentialsHumansCortical evoked potentialsDBSDBS local Evoked potentialsParkinson's disease

Identifiers

PMID35921959
PMCPMC9588756
OpenAlexW4288926418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.