Evidence map›Paper›PMID 35921771›Full record

ArticleEnvironment international2022

Associations between airborne crude oil chemicals and symptom-based asthma.

Kaitlyn G Lawrence, Nicole M Niehoff, Alexander P Keil, W Braxton Jackson, Kate Christenbury, Patricia A Stewart, Mark R Stenzel, Tran B Huynh, Caroline P Groth, Gurumurthy Ramachandran and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kaitlyn G LawrenceEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Alexander P KeilEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.
W Braxton JacksonSocial and Scientific Systems Inc, a DLH Holdings company, Durham, NC, USA.
Kate ChristenburySocial and Scientific Systems Inc, a DLH Holdings company, Durham, NC, USA.
Patricia A StewartStewart Exposure Assessments, LLC, Arlington, VA, USA.
Mark R StenzelExposure Assessment Applications, LLC, Arlington, VA, USA.
Tran B HuynhDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Caroline P GrothDepartment of Epidemiology and Biostatistics, West Virginia University, Morgantown, WV, USA.
Gurumurthy RamachandranDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Sudipto BanerjeeDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Gregory C PrattDivision of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Matthew D CurrySocial and Scientific Systems Inc, a DLH Holdings company, Durham, NC, USA.
Lawrence S EngelEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Electronic address: sandler@niehs.nih.gov.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Gulf Longitudinal Follow-up (GuLF) Worker StudyZIAES102945 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2010 to 2025
$15.3M
Intramural NIH HHS ZIA ES102945NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

rationaleThe 2010 Deepwater Horizon (DWH) oil spill response and cleanup (OSRC) workers were exposed to airborne total hydrocarbons (THC), benzene, toluene, ethylbenzene, o-, m-, and p-xylenes and n-hexane (BTEX-H) from crude oil and PM

objectivesWe assessed the relationship between asthma and several oil spill-related exposures including job classes, THC, individual BTEX-H chemicals, the BTEX-H mixture, and PM

methodsOur analysis largely focused on the 19,018 workers without asthma before the spill who had complete exposure, outcome, and covariate information. We defined incident asthma 1-3 years following exposure using both self-reported wheeze and self-reported physician diagnosis of asthma. THC and BTEX-H were assigned to participants based on measurement data and work histories, while PM

resultsOSRC workers had greater asthma risk than nonworkers (RR: 1.60, 95% CI: 1.38, 1.85). Higher estimated THC exposure levels were associated with increased risk in an exposure-dependent manner (linear trend test p < 0.0001). Asthma risk also increased with increasing exposure to individual BTEX-H chemicals and the chemical mixture: A simultaneous quartile increase in the BTEX-H mixture was associated with an increased asthma risk of 1.45 (95% CI: 1.35,1.55). With fewer cases, associations were less apparent for physician-diagnosed asthma alone.

conclusionsTHC and BTEX-H were associated with increased asthma risk defined using wheeze symptoms as well as a physician diagnosis.

Indexed as

AsthmaPetroleumPetroleum PollutionBenzeneHumansHydrocarbonsParticulate MatterProspective StudiesBenzeneHydrocarbonsParticulate MatterPetroleumAsthmaBTEX-HMixturesOil spillsTotal hydrocarbonsVolatile organic compounds

Identifiers

PMID35921771
PMCPMC9378681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.