Evidence map›Paper›PMID 35921415›Full record

ArticleScience advances2022

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of

Alisha N Jones, Carina Graß, Isabel Meininger, Arie Geerlof, Melina Klostermann, Kathi Zarnack, Daniel Krappmann, Michael Sattler

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  5. Role of RNA in genome folding: It's all about affinity.Current opinion in structural biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alisha N JonesInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.ORCID 0000-0002-2084-3625
Carina GraßResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.
Isabel MeiningerResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.ORCID 0000-0001-7562-8853
Arie GeerlofInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.
Melina KlostermannBuchmann Institute for Molecular Life Sciences (BMLS) & Faculty of Biological Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.ORCID 0000-0003-3122-1095
Kathi ZarnackBuchmann Institute for Molecular Life Sciences (BMLS) & Faculty of Biological Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.ORCID 0000-0003-3527-3378
Daniel KrappmannResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.ORCID 0000-0001-7640-3234
Michael SattlerInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 München, Germany.ORCID 0000-0002-1594-0527
Helmholtz Zentrum München · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing plays key roles for cell type-specific regulation of protein function. It is controlled by cis-regulatory RNA elements that are recognized by RNA binding proteins (RBPs). The MALT1 paracaspase is a key factor of signaling pathways that mediate innate and adaptive immune responses. Alternative splicing of

Indexed as

Heterogeneous-Nuclear Ribonucleoprotein LRNA PrecursorsAlternative SplicingBinding SitesExonsHeterogeneous-Nuclear RibonucleoproteinsHeterogeneous-Nuclear Ribonucleoprotein UMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinRNA-Binding ProteinsRNA Splice SitesHeterogeneous-Nuclear Ribonucleoprotein LHeterogeneous-Nuclear RibonucleoproteinsHeterogeneous-Nuclear Ribonucleoprotein UMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinRNA-Binding ProteinsRNA PrecursorsRNA Splice Sites

Identifiers

PMID35921415
PMCPMC9348792
OpenAlexW4289653535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.