ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023
Likely change indexes improve estimates of individual change on patient-reported outcomes.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Psychometric evaluation of the NFOSI-18 disease related symptoms - Physical, NFOSI-18 Total, and FACT GP5 in the recurrent ovarian cancer phase III study GY004.Gynecologic oncology · 2026Trial
- Validity, reliability, responsiveness, and clinically meaningful change threshold estimates of the National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index (NFBSI-16).Journal of patient-reported outcomes · 2024Trial
- Patient-reported outcomes as markers and predictors of functional recovery in musculoskeletal rehabilitation.Rheumatology international · 2026Review
- Measurement properties of the USER-Participation Restriction subscale and PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Coefficients of Repeatability for Likely Change: Comparison between PROMIS Computer Adaptive Tests and Short Forms.Advances in patient-reported outcomes · 2026Article
- Psychometric Properties and Prognostic Value of the UCSD Shortness of Breath Questionnaire in Hypersensitivity Pneumonitis: A Prospective Cohort Study.medRxiv : the preprint server for health sciences · 2025Article
- A perspective on the use of patient-reported experience and patient-reported outcome measures in ambulatory healthcare.Expert review of pharmacoeconomics & outcomes research · 2025Review
- Clinically meaningful improvements after gene therapy for aromatic L-amino acid decarboxylase deficiency (AADCd) in the Peabody Developmental Motor Scale, Second Edition (PDMS-2) and correlation with Bayley-III scores and motor milestones.Orphanet journal of rare diseases · 2025Article
- Interstitial Lung Disease Patients' Global Impressions of Symptoms, Severity Ratings, and Meaningfulness of Changes Over Time.Annals of the American Thoracic Society · 2024Article
- Significant individual change should be used as a lower bound for anchor based estimates of meaningful change on patient-reported outcome scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Commentary on "When (Not) to Rely on the Reliable Change Index".Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2024Article
- Linking QuickDASH and PROMIS Upper-Extremity Computer-Adaptive Test Scores in Hand Surgery: A Crosswalk Study.The Journal of hand surgery · 2024Article
- The challenge of using patient reported outcome measures in clinical practice: how do we get there?Journal of patient-reported outcomes · 2024Article
- Estimating individual health-related quality of life changes in low back pain patients.BMC musculoskeletal disorders · 2023Article
- Psychometric performance of the Primary Mitochondrial Myopathy Symptom Assessment (PMMSA) in a randomized, double-blind, placebo-controlled crossover study in subjects with mitochondrial disease.Journal of patient-reported outcomes · 2022Article
- Interpretation of Change in Novel Digital Measures: A Statistical Review and Tutorial.Digital biomarkersReview
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
purposeIndividual change on a patient-reported outcome (PRO) measure can be assessed by statistical significance and meaningfulness to patients. We explored the relationship between these two criteria by varying the confidence levels of the coefficient of repeatability (CR) on the Patient-Reported Outcomes Measurement Information System (R) Physical Function (PF) 10a (PF10a) measure.
methodsIn a sample of 1129 adult cancer patients, we estimated individual-change thresholds on the PF10a from baseline to 6 weeks later with the CR at 50%, 68%, and 95% confidence. We also assessed agreement with group- and individual-level thresholds from anchor-based methods [mean change and receiver operating characteristic (ROC) curve] using a PF-specific patient global impression of change (PGIC).
resultsCRs at 50%, 68%, and 95% confidence were 3, 4, and 7 raw score points, respectively. The ROC- and mean-change-based thresholds for deterioration were -4 and -6; for improvement they were both 2. Kappas for agreement between anchor-based thresholds and CRs for deterioration ranged between κ = 0.65 and 1.00, while for improvement, they ranged between 0.35 and 0.83. Agreement between the PGIC and all CRs always fell below "good" (κ < 0.40) for deterioration (0.30-0.33) and were lower for improvement (0.16-0.28).
conclusionsIn comparison to the CR at 95% confidence, CRs at 50% and 68% confidence (considered likely change indexes) have the advantage of maximizing the proportion of patients appropriately classified as changed according to statistical significance and meaningfulness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.