Evidence map›Paper›PMID 35920994›Full record

SynthesisAging clinical and experimental research2022

Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.

Lorenzo Lippi, Francesca Uberti, Arianna Folli, Alessio Turco, Claudio Curci, Francesco d'Abrosca, Alessandro de Sire, Marco Invernizzi

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  8. Frontiers in pain research (Lausanne, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lorenzo LippiDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy. lorenzolippi.mt@gmail.com.ORCID http://orcid.org/0000-0001-9035-1485
Francesca UbertiLaboratory of Physiology, Department of Translational Medicine, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Arianna FolliDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy.
Alessio TurcoDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy.
Claudio CurciPhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, Mantua, Italy.
Francesco d'AbroscaDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy.
Alessandro de SireDepartment of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
Marco InvernizziDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Carlo Poma · ITMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, the mitochondrial function has been related to several pathways involved in the cellular aging process. Dietary supplements might have reciprocal and multilevel interactions with mitochondria network; however, no systematic review assessed the role of different nutraceuticals in mitochondria modification of healthy older adults.

aimTo assess the effects of different dietary supplements on mitochondria modifications in older adults.

methodsOn February 22, 2022, PubMed, Scopus, Web of Science, and Cochrane were systematically searched from inception for randomized controlled trials (RCTs). According to PICO model, we considered healthy older adults as participants, nutraceutical treatment as intervention, any treatment as comparator, mitochondrial modifications as outcome. Jadad scale was used for the quality assessment.

resultsAltogether, 8489 records were identified and screened until 6 studies were included. A total of 201 healthy older adults were included in the systematic review (mean age ranged from 67.0 ± 1.0 years to 76.0 ± 5.6 years). The dietary supplements assessed were sodium nitrite, N-3 polyunsaturated fatty acids, hydrogen-rich water, nicotinamide riboside, urolithin A, and whey protein powder. Positive effects were reported in terms of mitochondrial oxidative and antioxidant capacity, volume, bioenergetic capacity, and mitochondrial transcriptome based on the nutritional supplements. The quality assessment underlined that all the studies included were of good quality. DISCUSSION: Although dietary supplements might provide positive effects on mitochondria modifications, few studies are currently available in this field.

conclusionFurther studies are needed to better elucidate the reciprocal and multilevel interactions between nutraceuticals, mitochondria, and environmental stressors in healthy older adults.

Indexed as

Fatty Acids, Omega-3Healthy AgingAgedDietary SupplementsHumansMitochondriaRandomized Controlled Trials as TopicFatty Acids, Omega-3AgingDietary supplementsMitochondriaMusclePrecision medicineRehabilitation

Identifiers

PMID35920994
OpenAlexW4289550031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.