ArticleHead and neck pathology2022
Human Papillomavirus-Associated Combined Neuroendocrine and Squamous Cell Carcinoma of the Sinonasal Tract.
Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the foreskin: a case report and literature review.Virchows Archiv : an international journal of pathology · 2026Article
- Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature.Head and neck pathology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combined neuroendocrine and squamous cell carcinoma (SCC) of the sinonasal tract is rare entity but is increasingly gaining recognition within the head and neck pathology community. In a recent series, a single case was reported to demonstrate diffuse p16 positivity despite lacking high-risk human papillomavirus (HPV) by RNA in-situ hybridisation (ISH). Here we describe a case of p16 positive combined neuroendocrine and SCC containing high-risk HPV. Retrospective case review of sinonasal carcinomas within the Head and Neck Pathology Department at Guy's and St Thomas' NHS Foundation Trust identified a single case of combined neuroendocrine and SCC. Clinico-demographic data was obtained through electronic hospital records. All immunohistochemistry and in-situ hybridisation were undertaken according to departmental standard operating procedures. Routine microscopy showed the tumour to comprise small and large cell neuroendocrine components as well as squamous and spindle cell elements. Small and large cells demonstrated CD56 and synaptophysin expression, whereas CK5/6 and p63 were confined to squamous components. There was diffuse p16 expression and punctate nuclear positivity for DNA ISH. We describe a case of HPV-associated combined neuroendocrine and SCC of the sinonasal tract. Recognition of HPV association with this entity avoids diagnostic pitfalls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.