Evidence map›Paper›PMID 35920790›Full record

ArticleHead & neck2022

Posttreatment FDG-PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma.

Jacob A Miller, Farshad Moradi, Vandana Sundaram, Rachel Liang, Carrie Zhang, Ngan Kim Nguyen, Faisal Akhtar, Yuhan Liu, Yulan Ren, Nima Harandi and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Effectiveness of Head-and-Neck Molecular Imaging Reporting and Data System Criterion in Head-and-Neck Squamous Cell Carcinoma PostConcurrent Chemoradiotherapy.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Jacob A MillerDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.ORCID 0000-0002-8480-5492
Farshad MoradiDivision of Nuclear Medicine, Department of Radiology, Stanford Hospital and Clinics, Stanford, California, USA.
Vandana SundaramQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Rachel LiangDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Carrie ZhangDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Ngan Kim NguyenDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Faisal AkhtarDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Yuhan LiuQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Yulan RenDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Nima HarandiDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Yingjie WengQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Erqi L PollomDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Alexander Dimitrios ColevasDepartment of Medical Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Vasu DiviDivision of Head and Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine, Stanford, California, USA.
Floyd Christopher HolsingerDivision of Head and Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine, Stanford, California, USA.
Beth M BeadleDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.ORCID 0000-0001-5497-2831
Quynh-Thu LeDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Michael F GensheimerDepartment of Radiation Oncology, Stanford Hospital and Clinics, Stanford, California, USA.
Stanford Health Care · USQuantitative BioSciences · USStanford Medicine · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
NCI NIH HHS P30 CA124435
6 · The paper itself

Abstract

backgroundMetabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG-PET/CT.

methodsWe conducted a retrospective cohort study of patients with node-positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing-risks model.

resultsBetween 2004 and 2018, 259 patients were included with median follow-up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36-month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p < 0.001). PET/CTs performed ≤10 weeks after radiotherapy were associated with a four-fold increase in pathologically negative biopsies/surgeries (36% vs. 9%, p = 0.03). The AUC for LRR was 0.89 using a model integrating the Hopkins score.

conclusionsThe Hopkins Criteria predict LRR with high accuracy for OPSCC response assessment.

Indexed as

Head and Neck NeoplasmsOropharyngeal NeoplasmsFluorodeoxyglucose F18HumansNeoplasm Recurrence, LocalPositron Emission Tomography Computed TomographyRadiopharmaceuticalsRetrospective StudiesSquamous Cell Carcinoma of Head and NeckFluorodeoxyglucose F18RadiopharmaceuticalsHopkins criterialocoregional recurrenceoropharynx cancerPET/CTresponse assessment

Identifiers

PMID35920790
PMCPMC12825993
OpenAlexW4289595490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.