Evidence map›Paper›PMID 35919724›Full record

ArticleChemical science2022

Asymmetric synthesis of aryl/vinyl alkyl carbinol esters

Deli Sun, Xianghua Tao, Guobin Ma, Jifen Wang, Yunrong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deli SunSchool of Resources and Environmental Engineering, Shanghai Polytechnic University 2360 Jinhai Road Shanghai 201209 P. R. China wangjifen@sspu.edu.cn.ORCID https://orcid.org/0000-0003-3098-3717
Xianghua TaoCenter for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences, Shanghai University 99 Shangda Road Shanghai 200444 P. R. China yr_chen@shu.edu.cn maguobin@shu.edu.cn.
Guobin MaCenter for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences, Shanghai University 99 Shangda Road Shanghai 200444 P. R. China yr_chen@shu.edu.cn maguobin@shu.edu.cn.ORCID https://orcid.org/0000-0002-6291-8875
Jifen WangSchool of Resources and Environmental Engineering, Shanghai Polytechnic University 2360 Jinhai Road Shanghai 201209 P. R. China wangjifen@sspu.edu.cn.
Yunrong ChenCenter for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences, Shanghai University 99 Shangda Road Shanghai 200444 P. R. China yr_chen@shu.edu.cn maguobin@shu.edu.cn.ORCID https://orcid.org/0000-0001-6872-4943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report herein an asymmetric Ni-catalyzed cross-electrophile coupling approach to prepare enantioenriched aryl/vinyl alkyl carbinol esters through arylation/vinylation of easily accessible racemic 1-chloro-1-alkanol esters with aryl/vinyl electrophiles. The method features a broad substrate scope as demonstrated by more than 60 examples including the challenging chiral allylic esters. It tolerates a wide array of functional groups including alkenyl, carbonyl and free hydroxyl groups that may not survive in conventional carbonyl reduction and addition methods. The synthetic utility of the present work was showcased by facile preparation of a few key intermediates and the modification of chiral drugs and naturally occurring compounds. Finally, we describe an efficient one-pot procedure for this method.

Identifiers

PMID35919724
PMCPMC9297475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.