Evidence map›Paper›PMID 35919602›Full record

ArticleRSC advances2022

Anticancer potential of β-sitosterol and oleanolic acid as through inhibition of human estrogenic 17beta-hydroxysteroid dehydrogenase type-1 based on an

Alfinda Novi Kristanti, Nanik Siti Aminah, Imam Siswanto, Yosephine Sri Wulan Manuhara, Muhammad Ikhlas Abdjan, Andika Pramudya Wardana, Ei Ei Aung, Yoshiaki Takaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. In Vitro Investigation of the Cytotoxic and Antioxidant Activities ofAdvances in pharmacological and pharmaceutical sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfinda Novi KristantiDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.ORCID https://orcid.org/0000-0002-3023-7098
Nanik Siti AminahDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.ORCID https://orcid.org/0000-0002-2767-6006
Imam SiswantoDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.
Yosephine Sri Wulan ManuharaBiotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga Indonesia.
Muhammad Ikhlas AbdjanDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.
Andika Pramudya WardanaDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.
Ei Ei AungDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia alfinda-n-k@fst.unair.ac.id nanik-s-a@fst.unair.ac.id.
Yoshiaki TakayaFaculty of Pharmacy, Meijo University 150 Yagotoyama, Tempaku Nagoya 468-8503 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human estrogenic enzyme 17beta-hydroxysteroid dehydrogenase type-1 (HSD17B1) provides biosynthesis regulation of active estrogen in stimulating the development of breast cancer through cell proliferation. The β-sitosterol is classified as a steroid compound and is actually a type of triterpenoid compound that has a similar structure to a steroid. This similarity provides a great opportunity for the inhibitor candidate to bind to the HDS17B1 enzyme because of the template similarity on the active site. Several

Identifiers

PMID35919602
PMCPMC9278416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.